Prototype Drug Unit 5 & 7- Cefazolin

Question 1

Therapeutic classification

Answer 1

Antibacterial

Question 2

Pharmacologic classification

Answer 2

Cell wall inhibitor, first-generation cephalosporin

Question 3

Therapeutic effects and uses

Answer 3

Used for prophylaxis of bacterial infections caused by gram-positive organisms. It is not effective against MRSA. Used to treat infections of the respiratory tract, urinary tract, skin structures, biliary tract, bones, and joints. Used for genital infections, septicemia, and endocarditis.

Question 4

Mechanism of action

Answer 4

Inhibits the bacterial wall synthesis by binding to specific PBPs.

Question 5

Adverse effects

Answer 5

Rash and Diarrhea. Superinfections are likely when it is used for prolonged periods of time.

Question 6

Contraindications

Answer 6

Don’t give it to people who are allergic to it. Monitor people with kidney problems

Question 7

Drug interactions

Answer 7

Probenecid decreases the excretion. Nephrotoxic drugs like aminoglycosides or vancomycin increases risk for killing kidneys. Synergistic antimicrobial action with other antibiotics such as aztreonam, carapenems, and the penicillins. If taken with warfarin can increase the anticoagulant effects.