Prototype Drug Unit 5 & 7- Amphotericin B Deoxycholate

Question 1

Therapeutic classification

Answer 1

antifungal (systemic type)

Question 2

Pharmacologic classification

Answer 2

Polyene

Question 3

Therapeutic effects and uses

Answer 3

Used for treating severe systemic mycoses and may also be indicated for prophylactic antifungal therapy for immunosuppressant patients.

Question 4

What are the 3 types of amphotericin B

Answer 4

Liposomal amphotericin B
Amphotericin B lipid complex
Amphotericin B cholesteryl sulfate complex

Question 5

Mechanism of actions

Answer 5

Acts by binding to ergosterol in fungal cell membranes, causing them to be permeable

Question 6

Adverse effects

Answer 6

Hypoklemia, hypomagnesemia, rash, fever and chills, nausea, vomiting, anorexia, headache

Question 7

Black Box Warning

Answer 7

Nonliposomal form should only be used on patients with a potentially life-threatening fungal infection

Question 8

Contraindications

Answer 8

May cause shock if given too quickly. Should be withheld if blood urea nitrogen exceeds 40 mg/dL

Question 9

Drug interactions

Answer 9

Should not be taken with aminoglycosides, cyclosporine, vancomycin, carboplatin, and furosemide. Corticosteriods, skeletal muscle relaxants and thiazole can cause hypokalemia. Azoles should not be used with this drug