Prototype Drug Unit 5 & 7- Gentamicin (Aminoglycosides that end in -cin)

Question 1

Therapeutic classification

Answer 1

Antibacterial

Question 2

Pharmacologic classificaiton

Answer 2

Bacterial protein synthesis inhibitor, aminoglycoside

Question 3

Therapeutic effects and uses

Answer 3

Used for the treatment and prophylaxis of susceptible bacterial infections. Prescribed for serious infections caused by aerobic, gram-negative bacilli

Question 4

Mechanism of action

Answer 4

inhibits bacterial protein synthesis by binding to the 30S ribosomal unit.

Question 5

Adverse effects

Answer 5

Rash, nausea, vomiting, and fatigue, pain or inflammation at the injection site, tinnitus, diarrhea, dizziness

Question 6

Black Box Warning

Answer 6

May cause severe neurotoxicity, neuromuscular blockade and respiratory paralysis, nephrotoxicity

Question 7

Contraindications

Answer 7

Hypersensitivity, be careful giving it to patients who have problems with their kidneys or hearing.

Question 8

Drug interactions

Answer 8

Don’t use with other nephrotoxic drugs, Pencillins can inactivate aminoglycosides.