Prototype Drug Unit 6- Lisinopril

Question 1

Therapeutic classification

Answer 1

Antihypertensive

Question 2

Pharmacologic classification

Answer 2

ACE inhibitor

Question 3

Therapeutic effects and uses

Answer 3

Used to treat heart failure, hypertension, and acute myocardial infarction.

Question 4

Mechanism of action

Answer 4

Inhibits the action ACE, thus preventing the conversion of angiotensin 1 to angiotensin 2. Thus blood pressure is dropped.

Question 5

Adverse effects

Answer 5

Headache, dry cough, dizziness, orthostatic hypotension, rash

Question 6

Black box warning

Answer 6

Fetal injury and death may occur when ACE inhibitors are taken during pregnancy

Question 7

Contraindications

Answer 7

Patients with Hyperkalemia (too much potassium)
History of angiosdemia
Renal impairment= caution

Question 8

Drug interactions

Answer 8

Indomethacin and other NSAIDs= decrease antihypertensive activity.
NSAIDs also worsen preexisting renal disease.
Antihypertensives and diuretics= synergistic hypotension
Potassium supplements and potassium-sparing diuretics= hyperkalemia

Question 9

Herbal/food interactions

Answer 9

Hawthorn= additive hypotension

Question 10

Treatment of overdose

Answer 10

Normal saline or vasopressors or hemodialysis