Prototype Drug Unit 3 & 4- Trimethoprim-sulfamethoxazole

Question 1

Therapeutic classification

Answer 1

Antibacterial

Question 2

Pharmacologic classification

Answer 2

Folic acid inhibitor, sulfonamide

Question 3

Therapeutic uses and effects

Answer 3

Commonly used for UTIs

Question 4

Adverse effects

Answer 4

Nausea and vomiting

Question 5

Contraindications/precautions

Answer 5

Contraindications: hypersensitivity to sulfates or sulfonamides. People with folate-deficiency anemia, severe renal impairment

Question 6

Drug interactions

Answer 6

These drugs enhance oral anticoagulants. Methotrexate interferes with folate metabolism. Use with caution when taking diuretics.

Question 7

Herbal/food interactions

Answer 7

Potassium supplements

Question 8

Treatment of overdose

Answer 8

5 to 15 mg of leucovorin should be given daily of bone marrow depression occurs