TOXINS

Question 1

what are the types of toxins that affect the liver?

Answer 1

reyes syndrome
acetaminophen
alcoholic liver disease

Question 2

what are the major injury patterns of the liver from toxins?

Answer 2

fibrosis
cirrhosis
necrosis
hepatitis
fatty change

Question 3

occurs in children given ASA for viral induced fever; causes hepatocellular dysfunction without overt necrosis

extensive accumulation of micro fat droplets within hepatocytes

Answer 3

reyes syndrome

Question 4

causes fulminant acute hepatitis and hepatocellular necrosis with overdose

zone 3 perivenular, submassive or massive liver necrosis

toxicity mediated by metabolite NAPQI

Answer 4

acetaminophen toxicity

Question 5

alcohol liver disease has overlapping forms of other diseases, what are they?

Answer 5

steatosis
hepatitis
cirrhosis

Question 6

occurs even with moderate consumption; reversible

prominent in zone 3 (centrilobular)

Answer 6

hepatic steatosis

Question 7

ballooning and necrosis

mallory bodies-hyaline, suggestive of alcoholic steatohepatitis

acute lobular inflammation

Answer 7

alcoholic hepatitis