HIGH YIELD-TYPE I DM

Question 1

pathogenesis results from type I DM results from?

Answer 1

severe, absolute lack of insulin due to a reduction in B cell mass

Question 2

the mechs for islet of cell destruction are?

Answer 2

genetic susceptibility
autoimmunity
environmental insult

Question 3

it occurs more frequently in what descent of people?

Answer 3

northern european

Question 4

what are the genetic associations?

Answer 4

HLA-DR3

HLA-DR4

Question 5

disease that results from a chronic autoimmune attack on B cells

Answer 5

autoimmunity

Question 6

evidence of autoimmune reaction?

Answer 6

lymphocytic infiltrate

increased expression class I MHC molecules, class II MHC molecules

70-80% of type IA diabetics have islet cell autoantibodies

10-20% of type IA diabetics have other organ specific autoimmune disorders

Question 7

what are the environmental factors?

Answer 7

viruses-coxsackieviruses of group B

cows milk

chemical toxins