HIGH YIELD III (ACUTE RENAL FAILURE)

Question 1

most common cause of acute renal failure (disturbances

initiating (36 hrs)-slight decrease in urine output and increase in BUN

maintenance- salt and water overload

recovery- steady increase in urine volume (3L/day)

Answer 1

acute tubular necrosis

Question 2

important cause of renal injury

the types being, acute drug-induced interstitial nephritis and analgesic nephropathy

Answer 2

drug induced interstitial nephritis

Question 3

name this type of drug induced interstitial nephritis?

most frequently occurs with use of synthetic penicillin , other synthetic antibiotics, diuretics, NSAIDs, and misc drugs

• begins 15 days
• immunogenicity occurs because of hapten forming from drug
• note that histology slide shows prominent mononuclear and eosinophil infiltrate

*renal fxn returns after several months

Answer 3

acute drug induced interstitial nephritis

Question 4

name this type of drug induced interstitial nephritis?

chronic renal disease due to excessive intake of analgesic mixtures

-renal damage attributed to phenacetin; analgesic mixtures include aspirin, caffeine, acetaminophen, and codeine

name this drug from affects listed below that can cause analgesic nephropathy:

1) metabolites injure cells by covalent bonding and oxidative damage
2) decreases levels of pgs, decreasing vasodilatory effects

Answer 4

analgesic nephropathy

phenacetin
aspirin