SCLERODERMA Flashcards
1
Q
2 major categories?
A
diffuse scleroderma
localized scleroderma
2
Q
which category of scleroderma has CREST syndrome?
A
localized scleroderma
3
Q
what is the result of scleroderma?
A
ischemic injury
4
Q
scleroderma mainly effects?
A
skin -loss of adnexa, capillaries, thickened walls GI tract -reflux, barrett metaplasia MSK kidneys -HTN in 30% -malignant HTN in 20% lungs heart
5
Q
what immunologic abnormality is unique to scleroderma?
A
two ANAs
- Anti Scl70
- anticentromere antibody
- order labs to test for this
6
Q
major presentation?
A
raynauds phenom
CREST
7
Q
name this tissue disease?
clinical features of SLE, polymyositis, scleroderma
high titers of anti-RNP
paucity of renal disease, presents with raynauds phenom, esophageal motility dysfxn, myositis, leukopenia and anemia, fever adn lymphadenopathy
A
mixed connective tissue disease (MCTD)
