HIGH YIELD-PNEUMOCONIOSES

Question 1

what are the types?

Answer 1

coal workers pneumoconoisis 
silicosis
asbestos-related diseases
-asbestosis
-malignant mesothelioma

Question 2

development of pneumoconiosis depends on?

Answer 2

amount of dust retained in the lungs and airways***

size, shape, and buoyancy of particles

Question 3

what are the lung findings of coal workers pneumoconiosis (CWP)?

major cause?

Answer 3

anthracosis
simple CWP
complicated CWP

coal dust

Question 4

what is the difference of simple vs complicated CWP?

Answer 4

simple-no fibrosis and progresses to complicated CWP

complicated-extensive fibrosis, progressive massive fibrosis, blackened scars***

Question 5

morphology of CWP?

Answer 5

anthracosis
simple CWP
complicated CWP
caplan syndrome

Question 6

this morphology of CWP is the coexistance of RA with pneumoconiosis leading to development of distinctive nodular pulmonary lesions

Answer 6

caplan syndrome (UC)

Question 7

clinical s/s of CWP?

Answer 7

increased pulmonary dysfunction

pulmonary hypertension

cor pulmonale

Question 8

this is the most prevalent chronic occupational disease in the world

common in sandblasters and mine workers

occurs after decades of exposure

Answer 8

silicosis

Question 9

what forms of silica is more fibrogenic?

Answer 9

crystalline forms

Question 10

describe the morphology of silicosis, from acute progression to chronic?

Answer 10

early-tiny discrete nodules in upper zones of lung

as disease progresses, nodules coalesce into collagenous scars (cavitation and calcification)

Question 11

signs and symptoms of silicosis?

Answer 11

upper lobes
cor pulmonale
slow to kill
susceptibility to TB and lung cancer

Question 12

this is present in insulation, construction materials and can be brought home on workers clothes

Answer 12

asbestos

Question 13

localized fibrous pleural plaques

pleural effusions

parenchymal interstitial fibrosis

bronchogenic carcinoma

mesotheliomas

all associated with what disease?

Answer 13

asbestos

Question 14

2 major geometric forms?

*which form has been linked to mesothelioma?

Answer 14

serpentine
-curly and flexible, common

amphibole
-straight, stiff, more pathogenic

*amphibole

Question 15

form of asbestos is related to asbetosis?

characterized by?

Answer 15

amphibole

asbestos bodies

• golden brown, fusiform or bearded rods, fiber like
• if fiber not ID, look for ferruginous body

Question 16

what is this asbesto related disease?

visceral or parietal pleural
diffuse lesion
2 types
-mesenchymal stromal cell
-epithelial like cells

s/s
indistinguishable
dypsnea
productive cough
cor pulmonale

Answer 16

malignant mesothelioma

Question 17

what are the 2 cell types of malignant mesothelioma?

Answer 17

mesenchymal stromal cells
-sarcomatoid type B

epithelial like cells
-epithelial type A