HIGH YIELD-CHEMICAL, DRUG INJURY,ALCOHOL

Question 1

T/F, these can cause injury and death?

Answer 1

T

Question 2

2 major categories?

Answer 2

exaggeration of intended pharmacologic effect

unpredictable response

Question 3

therapeutic agents?

Answer 3

acetaminophen

aspirin

Question 4

therapeutic dose?

toxic dose?

Answer 4

0.5 g

15-25 g

Question 5

where is acetaminophen conjugated and where?

resulting?

Answer 5

liver with glucoronide sulfate to NAPQI (hepatic P450 system)

centrilobular hepatic necrosis

Question 6

what are fatal doses of aspirin?

Answer 6

2-4 g in children

10-30 g in adults

Question 7

this can develop in those who take more than or equal to 3 g daily of aspirin?

Answer 7

chronic aspirin toxicity

-headache, dizziness, tinnitus, difficulty hearing, confusion, drowsiness, N/V/D

Question 8

most widely abused drug in the world?

Answer 8

alcohol

Question 9

effects of alcohol use? acute, chronic?

Answer 9

acute: CNS depressant
- inhibitory neurons first
- cortical
- medullary

chronic:multiple organ 
system failure, liver
-cardiomyopathy
-wernicke syndrome (B1 deficiency)
-acute gastritis

Question 10

levels of alcohol for impairment?

Answer 10

20-30 mg/dl

Question 11

levels of alcohol for legal intoxication?

Answer 11

80-100 mg/dl

Question 12

levels of alcohol for narcosis?

Answer 12

200-250 mg/dl

Question 13

levels of alcohol for coma and fatal respiratory arrest?

Answer 13

300-400 mg/dl