HIGH YIELD-HYPERBILIRUBINEMIA

Question 1

elevated levels of bilirubin in the blood?

Answer 1

hyperbilirubinemia

Question 2

hallmark clinical sign?

Answer 2

jaundice

Question 3

composition of bile?

Answer 3

bile acids
bilirubin
cholesterol
waste products

Question 4

bilirubin cycle?

Answer 4

prehepatic phase
intrahepatic phase
posthepatic phase

Question 5

name this phase of the bilirubin cycle?

normal RBC senescence, bleeding, hemolysis, ineffective erythropoiesis leading to hemoglobin breakdown

Answer 5

prehepatic phase

Question 6

name this phase of the bilirubin cycle?

hepatocytes uptake bilirubin where it is conjugated to glucuronic acid

Answer 6

intrahepatic phase

Question 7

name this phase of the bilirubin cycle?

bile flows out of liver where it is released into GI tract

Answer 7

posthepatic phase

Question 8

basic mechanisms of hyperbilirubinemia?

Answer 8

increased production of bilirubin

impaired conjugation

impaired secretion

impaired bile transit

Question 9

measurement of conjugated bilirubin is?

Answer 9

direct

Question 10

measurement of unconjugated bilirubin is?

Answer 10

indirect