SLE

Question 1

name this disease:

F>M
black women
20-30 yrs
higher rate in monozygotic twins

Answer 1

SLE

Question 2

SLE is the failure to maintain?

Answer 2

self tolerance, leads to production of a large number of autoantibodies which can damage tissue directly or form immune complexes

Question 3

what is the HLA association?

Answer 3

HLA DR2

HLA DR3

Question 4

because this is an autoimmunologic disease what do antibodies develop resistance against?

what antibodies are diagnostic of SLE?

Answer 4

DNA
histones
non histone proteins bound to DNA
nuclear antigens

dsDNA and Sm antigen

Question 5

pts with SLE have a host of other antibodies directed against a host of elements like?

Answer 5

platelets
RBCs
phospholipid

Question 6

morphology of SLE?

Answer 6

skin
kidney
joints
CNS
CVD
spleen
lungs

Question 7

major clinical presentation of SLE?

Answer 7

butterfly rash, fever, pain

ANAs found in 100% of patients but ANAs not specific

Question 8

lupus variants?

Answer 8

chronic discoid lupus erythematosus

subacute cutaneous lupus erythematosus

drug induced lupus erythematosus