HIGH YIELD II (GLOMERULAR DISEASE) Flashcards
common cause in adults, 30-50 years, type of GD
slowly progressive disease characterized by diffused thickening of the glomerular capillary wall due to the accumulation of electron dense, Ig containing deposits along the sub epithelial side of the basement membrane
*special to note
membranous nephrophathy
*
- form of chronic immune complex mediated disease
- EM shows spike and dome
clinical course, name this type of kidney disease?
spontaneous remissions
relapsing nephrotic syndrome, normal renal fxn
renal failure of die
*also, this has the highest reported incidence of renal vein thrombosis, PE and DVT
membranous nephropathy
what is this disease again?
affects some but not all glomeruli, involves only segments of each glomerulus
aka: HIV infection < heroin addiction; sickle cell disease, massive obesity
focal segmental glomerulosclerosis
type I membranoproliferative glomerulonephritis affects?
whaddabout type II?
sub endothelial
-SLE, Hep-B, Hep-C, endocarditis, HIV
basement membrane
nephritic syndrome presents clinically with _____?
hematuria (red casts in urine), azotemia, oliguria, some proteinuria, HTN
what are the examples of nephritic syndrome?
acute postinfectious glomerulonephritis, acute proliferative
rapidly progressive (crescentic) GN
acute postinfectious glomerulonephritis, acute proliferative (part of nephritic syndrome) has what two presentations?
diffuse proliferative pattern
classic post-streptococcal
1-4 weeks after group A beta-hemolytic strep infection
so we know that rapidly progressive glomerulonephritis (GN) is part of nephritic syndrome, are there any types? if so name them…
yes
3 types, the first two are the most important
-Type I RPGN; autoimmune; Anti-GBM disease
(lung and kidney)***
-Type II RPGN;
immune complex mediated being a complication of any other immune complex nephritis
(granular)***
name this glomerular disease?
prominent IgA deposits in the mesangial regions on immunofluorescence
causes recurrent gross or microscopic hematuria
mild proteinuria, nephrotic syndrome
IgA nephropathy (Berger disease)
most common cause of GN worldwide
name this glomerular disease?
makes up 30-50% of patients requiring chronic hemodialysis
may be difficult to determine original disease process
chronic GN
represents the end stage of variety of entities
tubulointerstitial nephritis as a type of GD has what types?
acute pyelonephritis
*e coli, proteus, klebsiella, enterobacter
vesicoureteral reflux is a sign of what GD? be specific?
tubulointerstitial nephritis, subtype acute pyelonephritis
name this GD based on S/S?
sudden onset of pain at costovertebral angle (flank pain)
urethral and urinary bladder irritation
pyuria (WBC casts)
papillary necrosis
acute pyelonephritis, subtype of tubulointerstitial nephritis
this GD involves the pelvis and calyces with two types being chronic obstructive pyelonephritis and reflux nephropathy
may be insidious or present as acute recurrent pyelonephritis; polyuria and nocturia; may develop focal segmental glomerulonephritis
chronic pyelonephritis
