TERMS

Question 1

multisystem, chronic disease of autoimmune origin characterized by relapses and remission, affecting principally the skin, joints, kidney, heart and serosal membranes

Answer 1

SLE

Question 2

name this lupus variant?

skin involvement
scaly erythematous plaques
atrophic scars
face and scalp
immunoflourescence

35% are positive ANA, but rarely antibodies to dsDNA

Answer 2

chronic discoid lupus erythematosus

Question 3

name this lupus variant?

skin involvement
widespread but superficial
mild systemic disease
strong assoc with anti SS-A and with HLA-DR3

Answer 3

subacute cutaneous lupus erythematosus

Question 4

name this lupus variant?

lupus like syndrome develops in patients receiving certain drugs (hydralazine, procainamide, isoniazid, D-penicillamine)

Answer 4

drug-induced lupus erythematosus

Question 5

a clfinicopathologic entity characterized by dry eyes(keratoconjunctivitis sic) and dry mouth(xerostomia) from immunologically mediated destruction of lacrimal and salivary glands

Answer 5

sjogren’s syndrome

Question 6

excessive fibrosis in multiple tissues, obliterative vascular disease and evidence of autoimmunity

Answer 6

scleroderma

Question 7

describes a disease with clinical features of SLE, polymyositis and scleroderma and serologically by high titers of anti-RNP

paucity of renal disease
good response to corticosteroids

Answer 7

mixed connective tissue disease (MCTD)

Question 8

skin and muscle involvement found in children or adults

Answer 8

dermatomyositis

Question 9

symmetric proximal muscle weakness, no cutaneous involvement; occurs mainly in adults

Answer 9

polymyositis

Question 10

insidious beginning with asymmetric involvement of distal muscles

affects > 50 yr olds

Cd8+ cytotoxic T cells present

morphology: presence of rimmed vacuoles present in myocytes, vacuoles rimmed by basophilic granules, vacuolated fibers contain amyloid deposits

Answer 10

inclusion body myositis