CARCINOMAS OF DUCTAL ORIGIN

Question 1

80-90% of all ductal type tumors; 28,000 new cases/year

one of the top 5 causes of deaths in developed countries

metastasize to bile duct, stomach, liver

smoking, high fat intake

jaundice, pain, rapid weight loss

develop in head of pancreas

60% in the head, difficult to distinguish from fibrosing chronic pancreatitis

Answer 1

ductal adenocarcinoma

Question 2

mucinous non cystic

pools of mucin > 50% tumor

associated with intraductal papillary mucinous neoplasms and mucinous cystic neoplasms

M=F
mean age 61
5-year survival 55%

Answer 2

colloid carcinoma

Question 3

2% of all pancreatic cancers

more prevalent in the tail
pure squamous cancer is very rare

M:F=2:1; mean age 65
worse prognosis-medial survival 6 months
-ductal most common type

Answer 3

adenosquamous carcinoma

Question 4

poorly differentiated cells, pushing borders

inflammatory infiltrate

prognosis similar to ductal adenocarcinoma

Answer 4

medullary carcinoma

Question 5

sarcomatous spindle cell
anaplastic giant cell
usually body/tail
very poor prognosis

Answer 5

undifferentiated carcinoma