KEY POINTS I

Question 1

liver is divided into how many segments?

Answer 1

eight functional segments, with own biliary and vascular supply for surgical resections

Question 2

T/F, liver may undergo many injury patterns, each with its own numerous causes?

Answer 2

T

Question 3

this part of the liver is the most prone to injury?

Answer 3

liver parenchyma, zone 3

Question 4

these cells store vitamin A, responsible for secreting collagen in cirrhosis.

these cells stimulate the Ito cells through the elaboration of various cytokines

Answer 4

ito cells

inflammatory cells and injured hepatocytes

Question 5

one of the most dangerous complications of chronic liver disease, prone to rupture?

Answer 5

esophageal varices

Question 6

liver affects other organs like?

Answer 6

brain
kidney
lungs

Question 7

this has numerous causes, some of which are serious and others that are clincally inconsequential?

Answer 7

hyperbilirubinemia

Question 8

what are the basic effects of hyperbilirubinemia?

Answer 8

increased production of bilirubin

impaired conjugation

impaired secretion

impaired bile transit

Question 9

this drug causes fulminant acute hepatitis and hepatocellular necrosis when taken in overdose?

Answer 9

acetaminophen

Question 10

this drug has been linked to reye’s syndrome in children in the setting of viral illness?

Answer 10

acetyl-salicylic acid (aspirin)

Question 11

this syndrome causes hepatocellular dysfunction without overt necrosis?

Answer 11

reyes syndrome

Question 12

T/F is somewhat resistant to the ischemia due to its dual blood supply (portal and arterial)

Answer 12

T

Question 13

caused by obstruction of two or more major hepatic veins

Answer 13

budd-chiari syndrome

Question 14

nodular regenerative hyperplasia can resemble cirrhosis but lack?

Answer 14

fibrosis

Question 15

this is more common in women and can rupture during pregnancy causing disastrous hemorrhage

Answer 15

hepatic adenoma

Question 16

the leading worldwide cause of hepatocellular carcinoma

Answer 16

hepatitis B

Question 17

this is the most common autosomal recessive genetic disease among caucasians in the US and easily treatable?

Answer 17

hemochromatosis

Question 18

a heritable cause of both cirrhosis and emphysema?

Answer 18

alpha-1-antitrypsin deficiency