HIGH YIELD-CERVIX, CANCERS OF

Question 1

HPV DNA is detected in >85% of cervical carcinoma, what are the high risk types?

Answer 1

16,18, 31,33

Question 2

what are the specific viral oncogenes that are tranformed by HPV?

these bind where?

Answer 2

E6 and E7

E6 to p53 affected by HPV 16,18

E7 to Rb affected by HPV 31,33

Question 3

the quadrivalent HPV vaccine treats what types?

Answer 3

6,11,16,18
low risk-6,11
high risk-16,18

Question 4

major risk factors of HPV?

Answer 4

early age at 1st intercourse

multiple sex partners

male partner with multiple previous sex partners

Question 5

what are the disorders of the cervix? (name the one)

Answer 5

endocervical polyps

**soft, mucoid masses of varying size

**dilated endocervical glands

fibromyxoid stroma

inflammation and squamous metaplasia common

Question 6

what are the cancers of the cervix?

Answer 6

HPV
cervical intraepithelial neoplasia (CIN)
invasive squamous cell carcinoma (SCC)

Question 7

this cervical cancer precedes majority of cancers, continuum of morphologic changes; assoc with HPV

does not invariably progress

classified by nuclear atypia and maturation

Answer 7

cervical intraepithelial neoplasia (CIN)

Question 8

this cervical cancer is the most frequent type and evolves from CIN***, usually in younger women

s/s: vaginal bleeding, painful coitus, dysuria

what are the growth patterns?

Answer 8

invasive squamous cell carcinoma (SCC)

fungating
ulcerating
infiltrative