HIGH YIELD-AUTOIMMUNE DISEASES Flashcards
1
Q
designation of autoimmune diseases should be based on?
A
evidence of an autoimmune reaction
judgement that the immunologic findings are not secondary
lack of another identifiable cause
2
Q
what are the types of immunologic tolerance?
A
self tolerance
central tolerance
peripheral tolerance
3
Q
what are the types of peripheral tolerance?
A
clonal deletion
clonal anergy
peripheral suppression by T cells
4
Q
what are the mechanisms of autoimmune disease?
A
complex and multifactorial failure of self tolerance abnormal display of self antigens inflammation or initial immune response susceptibility genes genetic factors mutations and polymorphisms multigenic patterns of susceptibility selected non-HLA genes associated with autoimmune disease
5
Q
autoimmune reactions can be triggered by?
A
infections
6
Q
what are the tests for autoimmunity?
A
rheumatoid factor
anti nuclear antibodies (ANA)
7
Q
what is RF?
A
autoantibody against Fc portion of autologous IgG, of which the RF is IgM
