HIGH YIELD

Question 1

what are the tests of hepatocytic integrity?

Answer 1

aminotransferases

lactate dehydrogenase

Question 2

what are the types of aminotransferases?

Answer 2

serum aspartate aminotransferase

serum alanine aminotransferase

Question 3

this aminotransferase is present in many organs?

Answer 3

AST

-liver, skeletal muscle, cardiac muscle, pancreas

Question 4

this aminotransferase is present in liver, primarily in cytoplasm?

Answer 4

ALT

Question 5

damage to hepatocyte membrane causing release of cytoplasmic AST and ALT?

*different intracellular locations of AST and ALT play a role in diagnosis of liver disease

Answer 5

mild disease

Question 6

mitochondrial AST released, changing AST/ALT ration

*different intracellular locations of AST and ALT play a role in diagnosis of liver disease

Answer 6

severe disease

Question 7

what aminotransferase is found in disease with mitochondrial release?

Answer 7

AST

Question 8

what aminotransferase is found in disease with cytoplasmic release?

Answer 8

ALT

Question 9

name this test of hepatocyte integrity?

5 isoenzymes, LD4/LD5 as the major isoenzymes of the liver

occurs in assoc with circulatory changes and with other hepatocellular damage

total LD not useful as a screening test for liver function

Answer 9

lactate dehydrogenase