Chapter 9: Vitamin B6 (Pyridoxine) Flashcards
other names
pyridoxic acid
pyridoxal
pyrioxol
pyridoxamine
pyridoxine
pyridoxine b6 - chemistry
forms found in foods are (3)
pyridoxine, pyrixodal, pyridoxamine
pyridoxine b6 - chemistry
all forms can be converted to the coenzyme _____ (PLP) that transfers amino groups from amino acid to make nonessential amino acids, an action that is valuable in protein
pyridoxal phosphate
pyridoxine b6 - chemistry
the body degrade it to _____ that is excreted in the urine
pyridoxic acid
pyridoxine b6 - chemistry
in body tissues, it occurs primarily in the phosphorylated forms of _____ (2)
PLP and pyridoxamine phosphate
pyridoxine b6 - chemistry
not destroyed by _____ (2)
heat and acids
pyridoxine b6 - chemistry
destroyed in _____ by oxidation and ultraviolet light
alkaline solutions
pyridoxine b6 - chemistry
deoxypyrodoxine, methoxpyrodoxine, toxopyromidine, and isonicotinic acid hydrazide (INH) are what
antagonists
pyridoxine b6 - absorption, transport, and utilization
absorbed mainly in the _____ in its free form by passive diffusion
jejunum
pyridoxine b6 - absorption, transport, and utilization
dephosphorylated in the intestinal lumen by the enzyme _____
aklaline phosphatase
pyridoxine b6 - absorption, transport, and utilization
bound to albumin and transported to the _____, where pyridoxine and pyridoxamine are phosphorylated by kinase and converted to PLP by flavin-dependent oxidase
liver
pyridoxine b6 - absorption, transport, and utilization
_____ in the liver and kidneys can convert pyridoxal to pyridoxic acid
occurs when too much of the vitamin is absorbed
aldehyde oxidase
pyridoxine b6 - absorption, transport, and utilization
stores _____ of vitamin b6
250 mg
pyridoxine b6 - absorption, transport, and utilization
in muscles 80-90% of PLP is bound to the energy glycogen phosphorylase
-
pyridoxine b6 - functions
in the form of PLP, the vitamin functions as a _____ of more than 60 enzymes in the following biochemical reactions
coenzyme
pyridoxine b6 - amino acid metabolism
_____ where an amino group (NH2) is transferred from one compound to another
transamination
pyridoxine b6 - amino acid metabolism
_____ reactions where a carboxyl group (COOH) and (COO-) is moved from a compound
decarboxylation
pyridoxine b6 - amino acid metabolism
desulferative deamination of _____
cysteine
pyridoxine b6 - amino acid metabolism
dehyrative deamination of _____ (2)
serine and threonine
pyridoxine b6 - amino acid metabolism
may be beneficial against _____; a pinch nerve in the wrist that causes pain or numbness in the hand
carpal tunnel syndrome
pyridoxine b6 - amino acid metabolism
may alleviate pre-menstrual syndrome
-
pyridoxine b6 - amino acid metabolism
formation and degradation of ____
cytstathionine
pyridoxine b6 - amino acid metabolism
synthesis of neurotransmitters _____ and _____
serotonin and norepinephrine
pyridoxine b6 - amino acid metabolism
synthesis of _____ needed for myelin formation
sphingolipids