Chapter 9: Vitamin B6 (Pyridoxine) Flashcards

1
Q

other names

pyridoxic acid
pyridoxal
pyrioxol
pyridoxamine

A

pyridoxine

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2
Q

pyridoxine b6 - chemistry

forms found in foods are (3)

A

pyridoxine, pyrixodal, pyridoxamine

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3
Q

pyridoxine b6 - chemistry

all forms can be converted to the coenzyme _____ (PLP) that transfers amino groups from amino acid to make nonessential amino acids, an action that is valuable in protein

A

pyridoxal phosphate

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4
Q

pyridoxine b6 - chemistry

the body degrade it to _____ that is excreted in the urine

A

pyridoxic acid

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5
Q

pyridoxine b6 - chemistry

in body tissues, it occurs primarily in the phosphorylated forms of _____ (2)

A

PLP and pyridoxamine phosphate

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6
Q

pyridoxine b6 - chemistry

not destroyed by _____ (2)

A

heat and acids

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7
Q

pyridoxine b6 - chemistry

destroyed in _____ by oxidation and ultraviolet light

A

alkaline solutions

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8
Q

pyridoxine b6 - chemistry

deoxypyrodoxine, methoxpyrodoxine, toxopyromidine, and isonicotinic acid hydrazide (INH) are what

A

antagonists

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9
Q

pyridoxine b6 - absorption, transport, and utilization

absorbed mainly in the _____ in its free form by passive diffusion

A

jejunum

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10
Q

pyridoxine b6 - absorption, transport, and utilization

dephosphorylated in the intestinal lumen by the enzyme _____

A

aklaline phosphatase

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11
Q

pyridoxine b6 - absorption, transport, and utilization

bound to albumin and transported to the _____, where pyridoxine and pyridoxamine are phosphorylated by kinase and converted to PLP by flavin-dependent oxidase

A

liver

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12
Q

pyridoxine b6 - absorption, transport, and utilization

_____ in the liver and kidneys can convert pyridoxal to pyridoxic acid

occurs when too much of the vitamin is absorbed

A

aldehyde oxidase

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13
Q

pyridoxine b6 - absorption, transport, and utilization

stores _____ of vitamin b6

A

250 mg

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14
Q

pyridoxine b6 - absorption, transport, and utilization

in muscles 80-90% of PLP is bound to the energy glycogen phosphorylase

A

-

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15
Q

pyridoxine b6 - functions

in the form of PLP, the vitamin functions as a _____ of more than 60 enzymes in the following biochemical reactions

A

coenzyme

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16
Q

pyridoxine b6 - amino acid metabolism

_____ where an amino group (NH2) is transferred from one compound to another

A

transamination

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17
Q

pyridoxine b6 - amino acid metabolism

_____ reactions where a carboxyl group (COOH) and (COO-) is moved from a compound

A

decarboxylation

18
Q

pyridoxine b6 - amino acid metabolism

desulferative deamination of _____

19
Q

pyridoxine b6 - amino acid metabolism

dehyrative deamination of _____ (2)

A

serine and threonine

20
Q

pyridoxine b6 - amino acid metabolism

may be beneficial against _____; a pinch nerve in the wrist that causes pain or numbness in the hand

A

carpal tunnel syndrome

21
Q

pyridoxine b6 - amino acid metabolism

may alleviate pre-menstrual syndrome

22
Q

pyridoxine b6 - amino acid metabolism

formation and degradation of ____

A

cytstathionine

23
Q

pyridoxine b6 - amino acid metabolism

synthesis of neurotransmitters _____ and _____

A

serotonin and norepinephrine

24
Q

pyridoxine b6 - amino acid metabolism

synthesis of _____ needed for myelin formation

A

sphingolipids

25
pyridoxine b6 - amino acid metabolism synthesis of delta-amino levulinic acid a precursor of _____
heme
26
pyridoxine b6 - amino acid metabolism part of glycogen phosphorylase
-
27
pyridoxine b6 - amino acid metabolism transformation of tryptophan to _____
niacin
28
pyridoxine b6 - amino acid metabolism biosynthesis of coa in the
liver
29
pyridoxine b6 - amino acid metabolism production of ethanomaline and taurine
-
30
pyridoxine b6 - amino acid metabolism a coenzyme in lysine oxidase that is active in the biosynthesis of _____ (2)
elastin and collagen
31
pyridoxine b6 - amino acid metabolism metabolism of _____ fatty acids
unsaturated
32
pyridoxine b6 - amino acid metabolism has an important role in _____
glucocorticoid action
33
pyridoxine b6 - interactions with other nutrients closely related with (2) the 2 vitamins are needed for the activity of enzymes important for the normal metabolism of some forms of b6
riboflavin and niacin
34
pyridoxine b6 - deficiency (microcytic type) smooth tongue; cracked corners of the mouth, abnormal brain wave pattern, irritability, muscle twitching, convulsions, irritation of sweat glands, dermatitis, and kidney stones
anemia
35
pyridoxine b6 - recommended intake for adults (19-49 y/o) male and female
1.3
36
pyridoxine b6 - recommended intake for adults (50 - >70y/o) male
1.7 mg
37
pyridoxine b6 - recommended intake for adults (50 - >70y/o) female
1.6 mg
38
pyridoxine b6 - recommended intake for pregnant
0.6 mg
39
pyridoxine b6 - recommended intake for lactating
0.7
40
pyridoxine b6 - recommended intake drugs that increases the body's need for vitamin b6 are oral contraceptives, INH, and penicillamine
b6
41
pyridoxine b6 - food sources vegetable oils (corn, cotton, seed, olive, peanut); rice and wheat germ; whole grain cereals, legumes, nuts, and seeds esp. soybeans, banana, potatoes, liver, salmon/tuna,
iron