Chapter 17: Nutrient-Drug Interaction Flashcards
substance other than food intended for use in diagnosis, cure, mitigation, treatment, and prevention
drug
the result of the action between a drug and a nutrient that would not happen with the nutrient or drug alone
drug-nutrient interaction
a broad term that includes drug-nutrient interactions and the effect of a medication on nutritional status
food-drug interaction
the study of the interactions between drugs and their receptors and the series of events that result in a pharmacologic response
pharmacodynamics
a science that deals with the progressive movement and the alteration of chemical substances within the body
it is the study of the mathematical relationship among the absorption, distribution, metabolism, and excretion of individual medicines over time
pharmacokinetics
originally interpreted as physician-induced malnutrition
iatrogenic malnutrition
mechanisms of drug-nutrient interactions - alteration of food intake
medication that alters appetite
amphetamines
mechanisms of drug-nutrient interactions - alteration of food intake
medication that interferes with taste
amphetamines
mechanisms of drug-nutrient interactions - alteration of food intake
medication that causes nausea and vomiting
digitalis
mechanisms of drug-nutrient interactions - alteration of food intake
medication that changes salivary secretion/dry mouth
phenobarbital
mechanisms of drug-nutrient interactions - alteration of food intake
medication that causes sores/inflammation in the mouth
methotrexate
mechanisms of drug-nutrient interactions - alteration of nutrient absorption (luminal effect)
change in acid secretion
antacids
mechanisms of drug-nutrient interactions - alteration of nutrient absorption (luminal effect)
motility
laxatices
mechanisms of drug-nutrient interactions - alteration of nutrient absorption (luminal effect)
binding actions to nutrient
antacid binds P
mechanisms of drug-nutrient interactions - alteration of nutrient absorption (mucosal effect)
damage to intestinal mucosa caused by intensive therapies
-
mechanisms of drug-nutrient interactions - alteration of nutrient metabolism and utilization
structural analogues
warfarin to vitamin K
mechanisms of drug-nutrient interactions - alteration of nutrient metabolism and utilization
competitive inhibition
phenobarbital and folate
mechanisms of drug-nutrient interactions - alteration of nutrient metabolism and utilization
altered enzyme activity and pharmacologically active agents
Monoamine oxidase inhibitors (MAOI) and tyramine
mechanisms of drug-nutrient interactions - alteration of nutrient excretion
increased excretion
diuretics
mechanisms of drug-nutrient interactions - alteration of nutrient excretion
displacement of nutrients
aspirin and folate
effect of nutrient on drug actions
alteration of absorption of orally administered drugs (3)
-by changing stomach acidity
-stimulating digestive enzymes
-competing for absorptive sites
effect of nutrient on drug actions
alteration of drug distribution
-
effect of nutrient on drug actions
alteration of drugs’ metabolism and excretion by altering urine pH
-
effect of nutrient on drug actions
food exerting antagonistic pharmacologic action
-
effect of nutrient on drug actions
when taken with food, drugs absorption may slow down or completely not absorbed
-
relating to a lumen (= the inside space of a tube-shaped organ in the body)
luminal
effect of nutrient on drug actions
food taken with drugs produce less side effects
-
timing of oral medication with food intake
drugs taken on an _____ stomach
empty
timing of oral medication with food intake
drugs taken _____ hr before meal
timing of oral medication with food intake
1/2
timing of oral medication with food intake
drugs taken with _____
meals
timing of oral medication with food intake
drugs taken _____ mins after meal
30-35 mins
timing of oral medication with food intake
drugs taken in a full glass of _____ (with or w/o meals)
water
