Chapter 10: Micromineral (Copper) Flashcards

1
Q

a cofactor for a wide range of enzymes; an essential element

A

copper

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2
Q

occurs in the cuprous and cupric form

A

copper

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3
Q

cu+

A

cuprous

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4
Q

cupric

A

cu2+

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5
Q

involved in oxidation-recution reactions

A

copper

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6
Q

body’s copper content ranges from

A

5-120 mg

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7
Q

highest concentration of the mineral is in the _____

A

liver

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8
Q

lesser amounts of the mineral is in the _____ (4)

A

heart, kidneys, spleen, and brain

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9
Q

copper in the blood and tissues is normally bound to

A

proteins

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10
Q

copper - functions

essential as an activator of key enzymatic reactions

A

copper

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11
Q

copper - functions

catalyzed the oxidation of the cytochrome C, a and a3 complex by oxygen in the respiratory chain

A

cytochrome c oxidase

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12
Q

copper - functions

(a) oxidizes ferrous ions to ferric ions; (b) transports copper to tissue sites; (c) acts as a scavenger of free radicals and superoxide ions

A

ceruloplasmin

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13
Q

copper - functions

toxic oxygen removal

A

superoxide dismutase

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14
Q

copper - functions

collagen synthesis

A

lysyl oxidase

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15
Q

copper - functions

neurotransmitter synthesis

A

dopamine betahydroxylases

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16
Q

copper - functions

melanin synthesis

A

tyrosine oxidase

17
Q

copper - absorption and metabolism

about 20-45% of dietary copper is absorbed from all parts of the GI tract, including the _____ (2)

A

stomach and large intestine

18
Q

copper - absorption and metabolism

bind with proteins such as _____, which slows down Cu absorption in the blood

A

metallothionein

19
Q

copper - absorption and metabolism

removed from the plasma by the _____ from where it is either excreted into the bile or used in the synthesis of ceruloplasmin, the copper-containing enzyme

20
Q

the copper containing enzyme

A

ceruloplasmin

21
Q

copper - absorption and metabolism

released from the liver under the control of the _____

body utilized some of the plasma copper in the synthesis of superoxide dismutase in the bone marrow

A

adrenal gland

22
Q

copper - absorption and metabolism

copper is excreted in both the

A

feces and urine

23
Q

copper - interrelationship with other nutrients

high intake of _____ or _____ decreases the absorption of copper

A

iron or vitamin c

24
Q

copper - interrelationship with other nutrients

decreases copper absorption

25
copper - interrelationship with other nutrients is antagonistic to copper
calcium
26
copper - interrelationship with other nutrients copper forms complexes with _____ and _____, decreases copper absorption
molybdenum and sulfur
27
copper - food sources liver, shellfish (esp. oysters), nuts, mushrooms, whole grain cereals, and gelatin
common sources of copper
28
copper - deficiency copper deficiency results in _____ and _____ hypochromic anemia is indistinguishable from iron-deficiency anemia; suggests that copper is essential for iron metabolism
hypochromic anemia; connective tissue damage
29
copper - deficiency copper deficiency is seen among children with _____ and _____
protein deficiency iron deficiency anemia
30
copper - deficiency is also seen _____ (born with low copper reserves) fed modified cow's milk
premature infants
31
copper - deficiency symptoms include decreased serum copper and anemia, impaired glucose tolerance, poor wound healing, immune defects, central nervous system, and cdv
copper
32
copper - deficiency is an inherited disease of copper metabolism this condition is characterized by low serum copper and ceruloplasmin levels this disease prevents the release of Cu into the general population
menke's kinky hair syndrome
33
copper - deficiency symptoms include abnormal keratinization (resulting in kinky hair), low serum, and liver copper levels, bone and skeletal abnormalities, and. mental deterioration resulting in death
menke's kinky hair syndrome
34
copper - toxicity copper poisoning may occur with the intake of _____ stored in copper containers
acidic beverages
35
result in tachycardia, hypertension, jaundice, hemolytic anemia, uremia, and death
copper - toxicity
36
copper - toxicity a genetic disorder in which excess amounts of copper and deposited in the liver, kidney, cornea, and brain, producing symptoms like tremor, ascites, psychoses
wilson's disease