Chapter 10: Micromineral (Selenium) Flashcards
one of the body’s antioxidant nutrients, protecting the body against oxidative stress
selenium
found in minute amounts of the body, concentrated, and other glandular organs, blood, and muscles
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two forms of selenium present in food are
selenomethionine
selenocysteine
selenomethionine is synthesized by
plants
selenocysteine is synthesized by
animals
selenium - functions
as part of the enzyme _____, it catalyzes the breakdown of toxic hydroperoxidases, making the mineral an essential component of the body’s antioxidant defense system
glutathione peroxidase
selenium - functions
works with _____ to reduce free radicals that are generated through cellular processes
vitamin e
selenium - functions
also regulates thyroid hormone and oxidative reductions of vitamin c
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selenium - absorption and metabolism
bound to proteins (globulins and lipoproteins)
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selenium - absorption and metabolism
taken up by the rbc, liver, heart, spleen, nails, and tooth enamel
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selenium - absorption and metabolism
major routs of se excretion are _____ (50-60% of total amount excreted) and _____ (40-50% total excreted)
urinary; fecal
absorption site of selenium
duodenum and caecum
selenium - interrelationship with other nutrients
Se is a _____ sparer
vitamin e
selenium - interrelationship with other nutrients
Se protects against toxicity of Cd (Cadmium), Hg (Mercury), and Ag (Silver)
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selenium - interrelationship with other nutrients
the potency of _____ is reduced in methionine deficiency
selenomethionine
selenium - deficiency
clinical manifestations include pain and weakness, cardiomyopathy, and a loss of pigmentation (pseudo-albinism)
symptoms - selenium deficiency
selenium - deficiency
is a selenium deficiency related to low selenium intakes
this condition causes hear enlargement
keshan disease or kashin-beck disease
selenium - deficiency
keshan disease is also known as
kashin-beck disease
selenium - toxicity
loss of hair and nails, “garlic breath” odor, dental caries and dermatitis, peripheral neuropathy
irritability and fatigue, lesions of the skin and the nervous system
se toxicity
selenium - toxicity
can be caused by an excessive intake of Se usually provided in the supplement
Se is toxic at levels 20-30 times the requirement
selenosis-selenium poisoning
selenium - recommended intake
for adults (19->70 y/o) for males
38 ug
selenium - recommended intake
for adults (19->70 y/o) for females
33 ug
selenium - recommended intake
for pregnant
33 +4
selenium - recommended intake
for lactating
33 +9
selenium - food sources
seafoods, liver, meats, whole grain, and dairy products
food sources