6.7 - Hodgkin lymphoma Flashcards
1
Q
reed sternberg cells stain positive for ____ and ____
A
CD15, CD30
2
Q
what makes up the bulk of the tumor in HL?
A
reactive inflammatory cells
3
Q
what are the 4 types of HL?
A
- nodular sclerosis
- lymphocyte-rich
- mixed cellularity
- lymphocyte depleted
4
Q
what is the most common type of HL?
A
nodular sclerosis
5
Q
what is the presentation for the most common type of HL?
A
nodular sclerosis:
- enlarging cervical or mediastinal lymph node in a young adult, usually female
6
Q
what is the histology of nodular sclerosis HL?
A
- bands of sclerosis
- RS cells are present in lacunar cells
7
Q
which type of HL has the best prognosis?
A
lymphocyte-rich
8
Q
which HL subtype is often associated with abundant eosinophils? why?
A
mixed cellularity - RS cells produce IL-5
9
Q
which HL subtype is the most aggressive? in which groups is it usually seen?
A
- lymphocyte depleted
- elderly, HIV
