6.6 - Lymphoma Flashcards
what are the 3 subtypes of NHL?
- small B cell
- intermediate sized B cell
- large B cell
follicular lymphoma is what subtype of NHL?
small B cell
mantle cell lymphoma is what subtype of NHL?
small B cell
marginal zone lymphoma is what subtype of NHL?
small B cell
small lymphocytic lymphoma is what subtype of NHL?
small B cell
burkitt lymphoma is what subtype of NHL?
intermediate sized B cell
diffuse large B cell lymphoma is what subtype of NHL?
large B cell
which lymphoma consists of “B symptoms” - HL or NHL?
HL
how are HL and NHL differentiated based on spread?
- HL: contiguous, rarely extranodal
- NHL: diffuse, often extranodal
what guides therapy in HL?
staging
what is the mainstay treatment for HL?
radiation
does leukemic phase occur in NHL? what about HL?
- NHL: yes
- HL: no
follicular lymphoma is driven by what translocation? what genes are involved?
- t(14,18)
- BCL2 (chromosome 18) translocates to Ig heavy chain on chromosome 14
- overexpression of Bcl2 which inhibits apoptosis
what is the treatment for follicular lymphoma? what does it target?
rituximab (anti-CD20 antibody)
what is the feared complication of follicular lymphoma?
progression to diffuse large B cell lymphoma
how is follicular lymphoma differentiated from reactive follicular hyperplasia?
follicular lymphoma shows:
- disruption of normal lymph node architecture
- LACK of tingible body macrophages in germinal centers
- Bcl2 expression in follicles
- monoclonality
mantle cell lymphoma is driven by what translocation? what is the product?
- t(11,14)
- cyclin D1 (chromosome 11) translocated to Ig heavy chain on chromosome 14
- promotes G1/S transition in cell cycle via phosphorylation of proteins
hashimoto thyroiditis, sjogren syndrome, and H. pylori are associated with what lymphoma?
marginal zone lymphoma
what is the name of the cancer caused by marginal zone lymphoma in mucosal sites?
MALT lymphoma
burkitt lymphoma is associated with what virus?
EBV
burkitt lymphoma is driven by what translocation?
- t(8,14)
- c-myc translocates to Ig heavy chain on chromosome 14
- c-myc oncogene promotes cell growth
what is the classic histology of burkitt lymphoma?
“starry sky”
what is the most common NHL? is it benign or aggressive?
- diffuse large B cell
- aggressive (high grade)
- t(14,18)
- BCL2 (chromosome 18) translocates to Ig heavy chain on chromosome 14
- overexpression of Bcl2 which inhibits apoptosis
follicular lymphoma
- t(11,14)
- cyclin D1 (chromosome 11) translocated to Ig heavy chain on chromosome 14
- promotes G1/S transition in cell cycle via phosphorylation of proteins
mantle cell lymphoma
- t(8,14)
- c-myc translocates to Ig heavy chain on chromosome 14
burkitt lymphoma
“starry sky”
burkitt lymphoma
