1.5 - Amyloidosis Flashcards
where does amyloid deposit?
extracellular space
amyloid takes on what protein conformation?
beta pleated sheets
primary amyloidosis is systemic deposition of ____ amyloid, which is derived from _____________
- AL
- Ig light chain
secondary amyloidosis is systemic deposition of ____ amyloid, which is derived from _____________
- AA
- serum amyloid associated protein (SAA)
what type of molecule is SAA?
acute phase reactant
what is the etiology of familial mediterranean fever (FMF)? how does it present?
- SAA during attacks deposits as AA amyloid in tissues due to a dysfunction of neutrophils
- fever and acute serosal inflammation (mimics appendicitis, arthritis, MI)
what is the most common organ involved in amyloidosis? what does it ultimately lead to?
- kidney
- nephrotic syndrome
senile cardiac amyloidosis is due to ___________ (mutated / non-mutated) serum ___________ deposits in the heart
- non-mutated
- transthyretin
is senile cardiac amyloidosis symptomatic or asymptomatic?
asymptomatic
familial amyloid cardiomyopathy is due to ____________ (mutated / non-mutated) serum ___________ in the heart
- mutated
- transthyretin
familial amyloid cardiomyopathy ultimately leads to what type of cardiomyopathy?
restrictive
the amylin in non-insulin dependent DM is derived from _________ deposits in the _______ of the pancreas
- insulin
- islets
dialysis associated amyloidosis is due to deposition of ________ in the joints
beta-2 microglobulin
FNA of the thyroid shows “tumor cells in an amyloid background” - diagnosis?
medullary carcinoma of the thyroid