1.5 - Amyloidosis Flashcards

1
Q

where does amyloid deposit?

A

extracellular space

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2
Q

amyloid takes on what protein conformation?

A

beta pleated sheets

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3
Q

primary amyloidosis is systemic deposition of ____ amyloid, which is derived from _____________

A
  • AL

- Ig light chain

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4
Q

secondary amyloidosis is systemic deposition of ____ amyloid, which is derived from _____________

A
  • AA

- serum amyloid associated protein (SAA)

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5
Q

what type of molecule is SAA?

A

acute phase reactant

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6
Q

what is the etiology of familial mediterranean fever (FMF)? how does it present?

A
  • SAA during attacks deposits as AA amyloid in tissues due to a dysfunction of neutrophils
  • fever and acute serosal inflammation (mimics appendicitis, arthritis, MI)
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7
Q

what is the most common organ involved in amyloidosis? what does it ultimately lead to?

A
  • kidney

- nephrotic syndrome

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8
Q

senile cardiac amyloidosis is due to ___________ (mutated / non-mutated) serum ___________ deposits in the heart

A
  • non-mutated

- transthyretin

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9
Q

is senile cardiac amyloidosis symptomatic or asymptomatic?

A

asymptomatic

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10
Q

familial amyloid cardiomyopathy is due to ____________ (mutated / non-mutated) serum ___________ in the heart

A
  • mutated

- transthyretin

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11
Q

familial amyloid cardiomyopathy ultimately leads to what type of cardiomyopathy?

A

restrictive

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12
Q

the amylin in non-insulin dependent DM is derived from _________ deposits in the _______ of the pancreas

A
  • insulin

- islets

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13
Q

dialysis associated amyloidosis is due to deposition of ________ in the joints

A

beta-2 microglobulin

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14
Q

FNA of the thyroid shows “tumor cells in an amyloid background” - diagnosis?

A

medullary carcinoma of the thyroid

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