6.3 - Chronic leukemia Flashcards

1
Q

neoplastic proliferation of naive B cells that coo-express CD5 and CD20

A

CLL

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2
Q

smudge cells are seen in ________

A

CLL

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3
Q

what is the hallmark blood smear finding in CLL?

A

smudge cells

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4
Q

what is a richter transformation?

A

transformation of CLL to diffuse large B cell lymphoma

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5
Q

hairy cell leukemia is a neoplastic proliferation of mature ___ cells

A

B

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6
Q

hairy cell leukemia B cells stain positive for _______

A

TRAP

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7
Q

hairy cell leukemia has excellent response to which drug? what is the MOA?

A
  • 2-CDA (cladribine)

- aenosine deaminase inhibitor, adenosine accumulates to toxic levels in neoplastic B cells

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8
Q

adult T cell leukemia / lymphoma is associated with what virus?

A

HTLV-1

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9
Q

adult T cell leukemia / lymphoma is a neoplastic proliferation of _________

A

mature CD4 T cells

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10
Q

what are the clinical features of adult T cell leukemia / lymphoma?

A
  • rash (skin infiltration)
  • generalized lymphadenopathy with hepatosplenomegaly
  • lytic (punched out) bone lesions with hypercalcemia
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11
Q

how can adult T cell leukemia / lymphoma (ATLL) be differentiated from multiple myeloma??

A

adult T cell leukemia / lymphoma has a RASH

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12
Q

T cell leukemias tend to manifest as _______

A

rashes

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13
Q

mycosis fungoides is a neoplastic proliferation of ____________

A

mature CD4 T cells

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14
Q

what are pautrier microbabscesses? what disease are they associated with?

A
  • aggregates of neoplastic cells in the epidermis

- mycosis fungoides

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15
Q

if neoplastic cells from mycosis fungoides spread to involve the blood, what condition results?

A

sezary syndrome

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16
Q

what characterizes sezary syndrome?

A

lymphocytes with CEREBRIFORM nuclei (sezary cells) on blood smear

17
Q

what are sezary cells?

A

lymphocytes with CEREBRIFORM nuclei

18
Q

what is the presentation for mycosis fungoides?

A
  • skin infiltration

- localized skin rash, plaques, nodules