6.3 - Chronic leukemia Flashcards
neoplastic proliferation of naive B cells that coo-express CD5 and CD20
CLL
smudge cells are seen in ________
CLL
what is the hallmark blood smear finding in CLL?
smudge cells
what is a richter transformation?
transformation of CLL to diffuse large B cell lymphoma
hairy cell leukemia is a neoplastic proliferation of mature ___ cells
B
hairy cell leukemia B cells stain positive for _______
TRAP
hairy cell leukemia has excellent response to which drug? what is the MOA?
- 2-CDA (cladribine)
- aenosine deaminase inhibitor, adenosine accumulates to toxic levels in neoplastic B cells
adult T cell leukemia / lymphoma is associated with what virus?
HTLV-1
adult T cell leukemia / lymphoma is a neoplastic proliferation of _________
mature CD4 T cells
what are the clinical features of adult T cell leukemia / lymphoma?
- rash (skin infiltration)
- generalized lymphadenopathy with hepatosplenomegaly
- lytic (punched out) bone lesions with hypercalcemia
how can adult T cell leukemia / lymphoma (ATLL) be differentiated from multiple myeloma??
adult T cell leukemia / lymphoma has a RASH
T cell leukemias tend to manifest as _______
rashes
mycosis fungoides is a neoplastic proliferation of ____________
mature CD4 T cells
what are pautrier microbabscesses? what disease are they associated with?
- aggregates of neoplastic cells in the epidermis
- mycosis fungoides
if neoplastic cells from mycosis fungoides spread to involve the blood, what condition results?
sezary syndrome