6.3 - Chronic leukemia Flashcards
neoplastic proliferation of naive B cells that coo-express CD5 and CD20
CLL
smudge cells are seen in ________
CLL
what is the hallmark blood smear finding in CLL?
smudge cells
what is a richter transformation?
transformation of CLL to diffuse large B cell lymphoma
hairy cell leukemia is a neoplastic proliferation of mature ___ cells
B
hairy cell leukemia B cells stain positive for _______
TRAP
hairy cell leukemia has excellent response to which drug? what is the MOA?
- 2-CDA (cladribine)
- aenosine deaminase inhibitor, adenosine accumulates to toxic levels in neoplastic B cells
adult T cell leukemia / lymphoma is associated with what virus?
HTLV-1
adult T cell leukemia / lymphoma is a neoplastic proliferation of _________
mature CD4 T cells
what are the clinical features of adult T cell leukemia / lymphoma?
- rash (skin infiltration)
- generalized lymphadenopathy with hepatosplenomegaly
- lytic (punched out) bone lesions with hypercalcemia
how can adult T cell leukemia / lymphoma (ATLL) be differentiated from multiple myeloma??
adult T cell leukemia / lymphoma has a RASH
T cell leukemias tend to manifest as _______
rashes
mycosis fungoides is a neoplastic proliferation of ____________
mature CD4 T cells
what are pautrier microbabscesses? what disease are they associated with?
- aggregates of neoplastic cells in the epidermis
- mycosis fungoides
if neoplastic cells from mycosis fungoides spread to involve the blood, what condition results?
sezary syndrome
what characterizes sezary syndrome?
lymphocytes with CEREBRIFORM nuclei (sezary cells) on blood smear
what are sezary cells?
lymphocytes with CEREBRIFORM nuclei
what is the presentation for mycosis fungoides?
- skin infiltration
- localized skin rash, plaques, nodules
