13.1 - Vulva Flashcards
the vulva is lined by ______________
squamous epithelium
unilateral, painful cystic lesion at the lower vestibule adjacent to the vaginal canal - diagnosis?
bartholin cyst
condyloma is due to which strains of HPV?
6 and 11
what is the histologic hallmark feature of condloma?
koilocytes
what are the high risk strains of HPV that can progress to carcinoma?
16, 18, 31, 33
what is lichen sclerosis? how does it present?
- thinning of the epidermis and fibrosis (sclerosis) of the dermis
- white patch (leukoplakia) with “parchment-like” vulvar skin
white patch (leukoplakia) with “parchment-like” vulvar skin - diagnosis?
lichen sclerosis
what is lichen simplex chronicus? what is the presentation?
- hyperplasia of the vulvar squamous epithelium
- leukoplakia with thick, leathery vulvar skin
- chronic irritation and scratching
- leukoplakia with thick, leathery vulvar skin
- chronic irritation and scratching
diagnosis?
lichen simplex chronicus
HPV related vulvar carcinoma is due to which HPV strains?
16 and 18
non HPV related vulvar carcinoma arises most often from what condition?
long standing lichen sclerosis
what is the defining feature of extramammary paget disease?
malignant epithelial cells in the epidermis of the vulva
how does extramammary paget disease present?
erythematous, pruritic, ulcerated vulvar skin
is there an underlying carcinoma in extramammary paget disease?
NO**
there is in paget disease of the breast, however
how can extramammary paget disease be distinguished from melanoma?
paget cells are:
- PAS positive**
- keratin positive**
- S100 positive
melanoma cells are:
- PAS negative**
- keratin negative**
- S100 positive
