3.1 - Neoplasia Flashcards
1
Q
what is the normal ratio of active isoforms in cells of any tissue?
A
1 : 1
2
Q
how can isoform differentiate between hyperplasia and neoplasia?
A
hyperplasia maintains a 1 : 1 ratio of isoforms
3
Q
how can clonality differentiate between hyperplasia and neoplasia?
A
neoplasia is monoclonal, hyperplasia is polyclonal
4
Q
clonality of B lymphocytes is determined by _______ phenotype
A
Ig light chain (kappa or lambda)
5
Q
what is the normal ratio of kappa to lambda light chains?
A
3 : 1
6
Q
top 3 cancers by incidence
A
- breast / prostate
- lung
- colorectal
7
Q
top 3 cancers by lethality
A
- lung
- breast / prostate
- colorectal
8
Q
how many divisions typically occur before the earliest clinical symptoms arise?
A
30
