1.3 - Cell death

Question 1

what type of necrosis is characteristics of ischemic infarction?

Answer 1

coagulative

Question 2

what is the gross appearance of coagulative necrosis?

Answer 2

wedge shaped and pale

Question 3

saponification is a an example of _____________ calcification

Answer 3

dystrophic

Question 4

what is the serum calcium level in dystrophic calcification?

Answer 4

normal

Question 5

what is the serum calcium level in metastatic calcification?

Answer 5

high

Question 6

fibrinoid necrosis occurs as a result of damage to ___________

Answer 6

blood vessel walls

Question 7

what type of necrosis occurs in malignant HTN and vasculitis?

Answer 7

fibrinoid

Question 8

preeclampsia would display what type of necrosis? why?

Answer 8

• fibrinoid

- damage to vessel walls

Question 9

in the intrinsic mitochondrial pathway of apoptosis, what molecule allows cytochrome c to leak from the inner mitochondrial matrix into the cytoplasm?

Answer 9

Bcl2

Question 10

what is the initial insult in the intrinsic mitochondrial pathway of apoptosis?

Answer 10

inactivation of Bcl2

Question 11

in the intrinsic mitochondrial pathway of apoptosis, lack of Bcl2 allows _____________ to leak from the inner mitochondrial matrix into the cytoplasm

Answer 11

cytochrome c

Question 12

in the extrinsic mitochondrial pathway of apoptosis, ____ binds ________ (CD ___) on the target cell, activating __________

Answer 12

• FAS-L
• FAS death receptor (CD95)
• caspases

Question 13

what are the two routes for extrinsic receptor ligand pathway of apoptosis?

Answer 13

• FAS - FAS-L
• TNF binding TNF receptor

both activate caspases

Question 14

in the cytotoxic CD8 T cell mediated pathway of apoptosis, what molecules lead to activation of caspases? how?

Answer 14

• perforins: create pores in membrane of target cell

- granzyme from CD 8 T cell enters pores and activates caspases