19.1 - Inflammatory dermatoses

Question 1

atopic dermatitis shows type _____ hypersensitivity

Answer 1

1

Question 2

contact dermatitis shows type _____ hypersensitivity

Answer 2

4

Question 3

what is the pathogenesis of acne vulgaris?

Answer 3

proprionibacterium acnes infection produces lipases that break down sebum, releasing proinflammatory fatty acids; results in pustule or nodule formation

Question 4

what are the two main treatment options for acne vulgaris? what do they target?

Answer 4

• benzoyl peroxide: antimicrobial

- vitamin A derivatives: reduce keratin production

Question 5

where is psoriasis usually seen?

Answer 5

EXTENSOR surfaces and scalp

Question 6

psoriasis is due to excessive ____________ (cell type) production

Answer 6

keratinocyte

Question 7

psoriasis has a proposed association with what HLA haplotype?

Answer 7

HLA-C

Question 8

what are the four main histological changes seen in psoriasis? which is responsible for the ‘silvery scale’?

Answer 8

1. acanthosis
2. parakeratosis
3. neutrophils in stratum corneum
4. elongated dermal papillae

parakeratosis is responsible for the silvery scale

Question 9

what is the morphology of lichen planus?

Answer 9

pruritic, planar, polygonal, purple papules

Question 10

what is the histology of lichen planus?

Answer 10

sawtooth appearance due to inflammation of dermal-epidermal junction