17.8 - CNS tumors

Question 1

where do metastatic brain tumors arise?

Answer 1

multiple, well circumscribed lesions at the gray-white junction

Question 2

which adult brain tumor crosses the corpus callosum?

Answer 2

GBM

Question 3

GBM stains positive for _____

Answer 3

GFAP

Question 4

why do meningiomas affect females more than males?

Answer 4

they have estrogen receptors

Question 5

schwannomas stain positive for ________

Answer 5

S-100

Question 6

bilateral schwannomas are seen in _________________

Answer 6

NF2

Question 7

• calcified tumor in the white matter, usually involving frontal lobe
• fried egg appearance

Answer 7

oligodendroglioma

Question 8

• cystic lesion with a mural nodule
• rosenthal fibers
• esosinophilic granular bodies
• GFAP positive

Answer 8

pilocytic astrocytoma

Question 9

what are rosenthal fibers? where are they seen?

Answer 9

• thick eosinophilic proceses of astrocytes

- pilocytic astrocytoma

Question 10

pilocytic astrocytomas stain positive for _____

Answer 10

GFAP

Question 11

• whorled patten

- psammoma bodies

Answer 11

meningioma

Question 12

regions of necrosis surrounded by tumor cells (pseudopalisading) and endothelial cell proliferation

Answer 12

GBM

Question 13

medulloblastomas are derived from what cell type and germ layer?

Answer 13

• granular cells of cerebellum

- neuroectoderm

Question 14

• small, round blue cells

- homer wright rosettes

Answer 14

medulloblastoma

Question 15

how do medulloblastomas spread?

Answer 15

via CSF

Question 16

what is a drop metastasis?

Answer 16

when medulloblastoma spreads via CSF to cauda equina

Question 17

perivascular rosettes

Answer 17

ependymoma

Question 18

ependymomas typically arise in which ventricle?

Answer 18

4th

Question 19

craniopharyngiomas arise from ______________

Answer 19

Rathke’s pouch