1.4 - Free radical injury Flashcards by Michael Gedestad | Brainscape

Q

in what part of the cell does catalase act?

A

peroxisome

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Q

in what part of the cell does SOD act?

A

mitochondria

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Q

in what part of the cell does glutathione peroxidase act?

A

mitochondria

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Q

carbon tetrachloride is converted to CCl3 by what system?

A

P450 system of hepatocytes

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Q

what is the pathogenesis of free radical injury of carbon tetrachloride - what organ is affected and why?

A

CCl4 is converted to CCl3 by P450 system of hepatocytes
cell injury with swelling of RER - ribosomes pop off, impairing protein synthesis
decreased apolipoproteins leads to FATTY CHANGE IN THE LIVER

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