17.4 - Cerebrovascular disease Flashcards
thrombotic strokes usually result in _________ (pale / hemorrhagic) infarcts
pale
embolic strokes usually result in _________ (pale / hemorrhagic) infarcts
hemorrhagic
embolic strokes usually involve which artery?
MCA
lacunar strokes occur secondary to _________ arteriolosclerosis, which is a complication of ___________
- hyaline
- HTN
lacunar strokes involving the internal capsule lead to a pure ________________ (motor / sensory) stroke
motor
lacunar strokes involving the thalamus lead to a pure ________________ (motor / sensory) stroke
sensory
what is the earliest histologic change following an ischemic stroke?
red neurons
what is the order of histologic change following ischemic strokes?
- red neurons (eosinophilic change in the cytoplasm)
- necrosis (24h)
- neutrophils (1-3d)
- microglial cells (4-7d)
- gliosis (2-3w)
what is reactive gliosis?
reactive astrocytes lining necrotic tissue
what occurs following an ischemic brain infarct in 12h?
red neurons
what occurs following an ischemic brain infarct in 24h?
necrosis
what occurs following an ischemic brain infarct in 1-3 days?
neutrophils
what occurs following an ischemic brain infarct in 4-7 days?
microglial cells
what occurs following an ischemic brain infarct in 2-3 weeks?
gliosis
when do red neurons appear following an ischemic brain infarct?
12h
when does necrosis occur following an ischemic brain infarct?
24h
when do neutrophils appear following an ischemic brain infarct?
1-3 days
when do microglial cells appear following an ischemic brain infarct?
4-7 days
when does gliosis occur following an ischemic brain infarct?
2-3 weeks
intracerebral hemorrhages are usually due to rupture of _________ microaneurysms of the ______________ arteries
- charcot bouchard
- lenticulostriate
what is the most common site of charcot bouchard aneurysms?
basal ganglia
