17.4 - Cerebrovascular disease

Question 1

thrombotic strokes usually result in _________ (pale / hemorrhagic) infarcts

Answer 1

pale

Question 2

embolic strokes usually result in _________ (pale / hemorrhagic) infarcts

Answer 2

hemorrhagic

Question 3

embolic strokes usually involve which artery?

Answer 3

MCA

Question 4

lacunar strokes occur secondary to _________ arteriolosclerosis, which is a complication of ___________

Answer 4

• hyaline

- HTN

Question 5

lacunar strokes involving the internal capsule lead to a pure ________________ (motor / sensory) stroke

Answer 5

motor

Question 6

lacunar strokes involving the thalamus lead to a pure ________________ (motor / sensory) stroke

Answer 6

sensory

Question 7

what is the earliest histologic change following an ischemic stroke?

Answer 7

red neurons

Question 8

what is the order of histologic change following ischemic strokes?

Answer 8

• red neurons (eosinophilic change in the cytoplasm)
• necrosis (24h)
• neutrophils (1-3d)
• microglial cells (4-7d)
• gliosis (2-3w)

Question 9

what is reactive gliosis?

Answer 9

reactive astrocytes lining necrotic tissue

Question 10

what occurs following an ischemic brain infarct in 12h?

Answer 10

red neurons

Question 11

what occurs following an ischemic brain infarct in 24h?

Answer 11

necrosis

Question 12

what occurs following an ischemic brain infarct in 1-3 days?

Answer 12

neutrophils

Question 13

what occurs following an ischemic brain infarct in 4-7 days?

Answer 13

microglial cells

Question 14

what occurs following an ischemic brain infarct in 2-3 weeks?

Answer 14

gliosis

Question 15

when do red neurons appear following an ischemic brain infarct?

Answer 15

12h

Question 16

when does necrosis occur following an ischemic brain infarct?

Answer 16

24h

Question 17

when do neutrophils appear following an ischemic brain infarct?

Answer 17

1-3 days

Question 18

when do microglial cells appear following an ischemic brain infarct?

Answer 18

4-7 days

Question 19

when does gliosis occur following an ischemic brain infarct?

Answer 19

2-3 weeks

Question 20

intracerebral hemorrhages are usually due to rupture of _________ microaneurysms of the ______________ arteries

Answer 20

• charcot bouchard

- lenticulostriate

Question 21

what is the most common site of charcot bouchard aneurysms?

Answer 21

basal ganglia