15.9 - Endocrine pancreas Flashcards

1
Q

type 1 DM is associated with what HLA types?

A

HLA-DR3 and HLA-DR4

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2
Q

what is the pathogenesis of DKA?

A
  • EPI stimulates glucagon secretion, increasing lipolysis
  • increased lipolysis leads to increased FFAs
  • liver converts FFA to ketone bodies
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3
Q

DKA results in ___________ (hypokalemia / hyperkalemia)

A

hyperkalemia

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4
Q

which has a stronger genetic predisposition - type 1 or type 2 DM?

A

type 2

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5
Q

in DM, nonenzymatic glycosylation of the kidneys occurs preferentially in the _________________ arteriole

A

efferent

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6
Q

what enzyme converts glucose to sorbitol?

A

aldose reductase

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7
Q
  • achlorhydria
  • cholelithiasis with steatorrhea

diagnosis?

A

somatostatinoma

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8
Q
  • watery diarrhea
  • hypokalemia
  • achlohydria

diagnosis?

A

VIPoma

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