15.9 - Endocrine pancreas Flashcards
1
Q
type 1 DM is associated with what HLA types?
A
HLA-DR3 and HLA-DR4
2
Q
what is the pathogenesis of DKA?
A
- EPI stimulates glucagon secretion, increasing lipolysis
- increased lipolysis leads to increased FFAs
- liver converts FFA to ketone bodies
3
Q
DKA results in ___________ (hypokalemia / hyperkalemia)
A
hyperkalemia
4
Q
which has a stronger genetic predisposition - type 1 or type 2 DM?
A
type 2
5
Q
in DM, nonenzymatic glycosylation of the kidneys occurs preferentially in the _________________ arteriole
A
efferent
6
Q
what enzyme converts glucose to sorbitol?
A
aldose reductase
7
Q
- achlorhydria
- cholelithiasis with steatorrhea
diagnosis?
A
somatostatinoma
8
Q
- watery diarrhea
- hypokalemia
- achlohydria
diagnosis?
A
VIPoma