17.7 - Dementia and degenerative disorders Flashcards
1
Q
in AD are tau aggregates intracellular or extracellular?
A
intracellular
2
Q
in AD there is a loss of cholinergic neurons in what nucleus?
A
nucleus of Meynert
3
Q
what is seen on histology in pick disease?
A
pick bodies - round aggregates of tau protein
4
Q
in PD lewy bodies are composed of ____________
A
alpha synuclein
5
Q
in HD there is a degeneration of ____ergic neurons in the ____________ of the basal ganglia
A
- GABA
- caudate nucleus
6
Q
what is the inheritance of HD?
A
AD
7
Q
HD is characterized by an expanded nucleotide repeat of ____ on the ___________ gene of chromosome ____
A
- CAG
- huntingin
- 4
8
Q
spongiform encephalopathy results from conversion to what protein conformation?
A
beta pleated sheets
9
Q
what is seen on EEG in spongiform encephalopathy?
A
periodic sharp waves
