3.2 - Carcinogenesis Flashcards
naphthylamine can cause what type of cancer? where is it found?
- urothelial carcinoma of bladder
- cigarette smoke
vinyl chloride can cause what type of cancer?
angiosarcoma of liver
aflatoxins can cause what type of cancer? where are they found?
- HCC
- aspergillus
chinese male with nasopharyngeal carcinoma - what is the organism responsible?
EBV
what are the high risk HBV types?
16, 18, 31, 33
ionizing radiation can cause what types of cancers? what is the mechanism?
- AML, CML, pap car of the thyroid
- hydroxyl free radicals
nonionizing radiation (UV) can cause what types of cancers? what is the mechanism?
- basal, squamous, melanoma
- pyrimidine dimers which are normally excised by restriction endonucleases
the ________ complex phosphorylates the Rb protein, which promotes progression through the G1/S checkpoint
cyclin D / CDK4
the cyclin D / CDK4 complex phosphorylates the ____ protein, which promotes progression through the __________ checkpoint
- Rb
- G1 / S
what protein regulates progression of the cell cycle from G1 to S phase?
p53 (and Rb)
what tumor is associated with PDGFB?
astrocytoma
what tumor is associated with KIT?
GI stromal
the RAS gene family serves what function normally?
GTP binding protein
what tumor is associated with c-MYC?
burkitt lymphoma
what is the translocation associated with burkitt lymphoma?
t(8;14) involving IgH