18.5 - Neuromuscular junction Flashcards
1
Q
what is the cause of myasthenia gravis?
A
autoantibodies against the postsynaptic acetylcholine receptor at the NMJ
2
Q
myasthenia gravis is associated with what disorders of the thymus? what can be helpful treatment-wise?
A
- thymic hyperplasia or thymoma
- thymectomy
3
Q
what is the cause of lambert eaton syndrome? what is the end result?
A
- autoantibodies against presynaptic calcium channels of the NMJ
- impaired Ach release
4
Q
what are the clinical features of lambert eaton syndrome?
A
- proximal muscle weakness that IMPROVES with use
- eyes are spared
- anticholinesterase agents do NOT improve symptoms
