15.8 - Parathyroid gland Flashcards
1
Q
what cells secrete PTH?
A
chief cells
2
Q
how does primary hyperPTH lead to increased urinary cAMP?
A
when PTH binds to tubular cells of kidney, that is coupled to a Gs protein - activates adenylyl cyclase
3
Q
- high PTH
- low serum calcium
- high serum phosphate
- high ALP
A
secondary hyperPTH
4
Q
what are symptoms of low calcium?
A
- numbness, tingling
- muscle spasms (tetany)
5
Q
what is the reason for end organ resistance to PTH in pseudohypoPTH?
A
defect in the Gs protein that binds PTH
6
Q
- hypocalcemia
- high PTH
- short stature
- short 4th and 5th digits
diagnosis? what is the cause?
A
- pseudohypoPTH
- defect in the Gs protein that binds PTH
7
Q
what is the inheritance of pseudohypoPTH?
A
AD
