16.3 - Breast cancer Flashcards
malignant proliferation of cells in ducts with no invasion of the basement membrane
ductal carcinoma in situ
what is the histology of comedo-type DCIS?
high grade cells with necrosis and dystrophic calcification in the center of ducts
what is paget disease of the breast?
DCIS that extends up the ducts to involve the skin of the nipple
how does paget disease of the breast present?
nipple ulceration and erythema
what is the most common carcinoma of the breast?
invasive ductal carcinoma
what does biopsy show in invasive ductal carcinoma?
duct-like structures in a desmoplastic stroma
duct-like structures in a desmoplastic stroma
invasive ductal carcinoma
what are the subtypes of invasive ductal carcinoma?
- TUBULAR: well differentiated tubules that lack myoepithelial cells
- MUCINOUS: abundant clear extracellular mucin
- MEDULLARY: large, high grade cells growing in sheets with associated lymphocytes and plasma cells
- INFLAMMATORY: carcinoma in dermal lymphatics
medullary carcinoma subtype carries an increased incidence of what gene mutation?
BRCA1
lobular carcinoma in situ (LCIS) is characterized by dyscohesive cells lacking what protein?
E-cadherin adhesion protein
lobular carcinoma in situ can be treated with what drug?
tamoxifen
what is the classic histology of invasive lobular carcinoma?
“Indian file” arrangement
why is there no duct formation in invasive lobular carcinoma?
lack of E-cadherin
“Indian file” arrangement is seen on a breast biopsy - diagnosis?
invasive lobular carcinoma
what is the most IMPORTANT factor of breast cancer prognosis?
metastasis
