18.3 - Joints Flashcards
degenerative joint disease consists of joint stiffness in the morning that ___________ (improves / worsens) during the day
worsens
how does degenerative joint disease differ from RA in terms of location?
- DJD: DIP and PIP involved
- RA: only PIP
heberden and bouchard nodes are involved in what disease? where are they located?
degenerative joint disease
- heberden: DIP
- bouchard: PIP
what is eburnation? eburnation of subchondral bone is seen in what condition?
- eburnation: “polishing”
- degenerative joint disease
RA is associated with what HLA?
DR4
what is the hallmark of RA?
synovitis leading to formation of a pannus (inflamed granulation tissue)
HLA-DR4 is associated with _______
RA
RA consists of joint stiffness in the morning that ___________ (improves / worsens) during the day
improves
what are the XR findings of RA?
- joint space narrowing
- loss of cartilage
- osteopenia
what are the extra-articular findings of RA?
- rheumatoid nodules: skin, visceral organs
- vasculitis
- baker cyst: popliteal
- pleural effusion
what is rheumatoid factor?
IgM autoantibody against Fc portion of IgG
what are the two main findings in synovial fluid in RA?
- neutrophils
- high protein
spondyloarthropathies are associated with what HLA?
B27
are spondyloarthropathies associated with rheumatoid factor?
no
ankylosing spondyloarthritis involves what joints?
SI and spine
bamboo spine is seen in what condition?
ankylosing spondyloarthritis
what are the extra-articular manifestations of ankylosing spondyloarthritis?
- uveitis
- aortitis (aortic regurgitation)
what is the triad of reiter syndrome?
- arthritis
- urethritis
- conjunctivitis
seronegative spondyloarthropathies arise in young adults (usually males) weeks after what types of infections?
- GI
- chlamydia trachomatis
sausage fingers (dactylitis) are seen in what condition?
psoriatic arthritis
what are the two main organisms responsible for infectious arthritis?
- n. gonorrhoeae
- s. aureus
is infectious arthritis monoarticular or polyarticular?
monoarticular
gout is due to deposition of what type of crystals?
monosodium urate
what cell type is seen in synovial fluid aspirate in gout?
neutrophils
pseudogout is due to deposition of what type of crystal? what is the crystal appearance?
- calcium pyrophosphate dihydrate (CPPD)
- rhomboid shaped crystals with weakly positive birefringence
