19.2 - Blistering dermatoses Flashcards
pemphigus vulgaris is due to an autoimmune destruction of __________, which are located between ______________
- desmosomes
- keratinocytes
pemphigus vulgaris is due to ____ antibody against _________; a type ____ hypersensitivity reaction
- IgG
- desmoglein
- type II
does pemphigus vulgaris involve the oral mucosa, or spare it?
involves oral mucosa
why does pemphigus vulgaris present with a tombstone appearance on histology?
basal layer cells are still intact, but upper layers are ripped off
thin walled bullae that rupture easily, leading to shallow erosions with a dried crust - diagnosis?
pemphigus vulgaris
what is the IF appearance of pemphigus vulgaris?
fish net pattern
bullous pemphigoid involves autoimmune destruction of ____________ between ______ cells and ___________
- hemidesmosomes
- basal
- basement membrane
bullous pemphigoid is due to _____ antibody against _________
- IgG
- hemidesmosome components BP180
tense bullae that do not rupture easily - diagnosis?
bullous pemphigoid
what is the IF appearance of bullous pemphigoid?
linear - IgG along basement membrane
dermatitis herpetiformis is due to _____ antibody deposition at __________
- IgA
- tips of dermal papillae
dermatitis herpetiformis has a strong association with what disease?
celiac disease
hypersensitivity reaction characterized by targetoid rash and bullae - diagnosis?
erythema multiforme
what is the name of the syndrome that consists of erythema multiforme that also involves the oral mucosa / lip and fever?
stevens johnson syndrome
how is stevens johnson syndrome associated with toxic epidermal necrosis?
TEN is a severe form of SJS characterized by diffuse sloughing of skin resembling a large burn
