4.3 - Other disorders of hemostasis Flashcards
1
Q
how does adenocarcinoma cause DIC?
A
mucin activates coagulation
2
Q
what are the lab findings in DIC?
- platelets
- PT / PTT
- fibrinogen
- D-dimer
A
- platelets: decreased
- PT / PTT: increased
- fibrinogen: decreased
- D-dimer: elevated
3
Q
what is the best screening test for DIC?
A
D-dimer
4
Q
D-dimer are derived from?
A
splitting of cross linked fibrin
5
Q
is D-dimer produced from the splitting of fibrin or fibrinogen?
A
FIBRIN
6
Q
disorders of fibrinolysis are due to overactivity of _________
A
plasmin
7
Q
what are the lab findings for disorders of fibrinolysis?
- PT / PTT
- bleeding time
- D-dimers
how is it differentiated from DIC?
A
- PT / PTT: increased
- bleeding time: increased
- D-dimers: NONE (fibrin thrombi are absent - fibrinogen is lysed, not fibrin)
8
Q
what is the treatment for disorders of fibrinolysis?
A
aminocaproic acid (blocks plasminogen)
