15.7 - Thyroid neoplasia

Question 1

• orphan annie eye nuclei
• nuclear grooves
• psammoma bodies

Answer 1

papillary carcinoma

Question 2

can a distinction between follicular adenoma and follicular carcinoma be made with FNA? why or why not?

Answer 2

no - need to examine entire capsule for invasion (carcinoma) - cannot do this with FNA

Question 3

how does follicular carcinoma spread? what other carcinomas can spread this way?

Answer 3

hematogenously

• RCC
• HCC
• follicular CA
• choriocarcinoma

Question 4

medullary carcinoma is a malignant proliferation of _______________ cells

Answer 4

parafollicular C

Question 5

C cells are ______________ cells that secrete ____________

Answer 5

• neuroendocrine

- calcitonin

Question 6

calcitonin often deposits within medullary carcinoma tumors as ___________

Answer 6

amyloid

Question 7

sheets of malignant cells in an amyloid stroma

Answer 7

medullary carcinoma of the thyroid

Question 8

medullary carcinoma is due to what MEN syndromes? they are associated with mutations in what gene?

Answer 8

• 2A and 2B

- RET

Question 9

detection of a RET mutation warrants what therapy?

Answer 9

total thyroidectomy