12.4 - Nephritic syndrome Flashcards
hypercellular, inflamed glomeruli are seen on biopsy from ________________ (nephritic / nephrotic) syndrome
nephritic
what mediates the damage seen in nephritic syndrome?
neutrophils, which are attracted by C5a
post strep GN arises after infection of what type of organism?
group A beta hemolytic strep infection of the skin (impetigo) or pharynx
what factor defines the nephritic strains of strep?
M protein
what are the H&E findings in post strep GN?
hypercellular, inflamed glomeruli
what are the IF findings in post strep GN?
granular
what are the EM findings in post strep GN?
subepithelial “humps”
what are the 3 types of RPGN?
- goodpasture
- PSGN
- wegener granulomatosis
- microscopic polyangiitis
- churg strauss
what differentiates churg strauss from microscopic polyangiitis?
churg strauss has:
- eosinophilia
- granulomatous inflammation
- asthma
what differentiates goodpasture syndrome from wegener / microscopic polyangiitis / churg strauss?
wegener / microscopic polyangiitis / churg strauss are associated with a prior infection
goodpasture is NOT assocaited with a prior infection
what is the IF pattern of wegener / microscopic polyangiitis / churg strauss?
negative (pauci immune)
what is the IF pattern of PSGN or diffuse proliferative GN?
granular
what is the IF pattern of goodpasture?
linear
- hematuria, hemoptysis in young adult males
- linear IF
goodpasture
where is the Ag-Ab complex deposition in PSGN?
subendothelial
what is the most common type of renal disease in SLE? what is its IF pattern?
- PSGN
- granular
wegener granulomatosis is associated with what autoantibody?
c-ANCA
microscopic polyangiitis is associated with what autoantibody?
p-ANCA
churg strauss is associated with what autoantibody?
p-ANCA
what are the H&E findings in RPGN?
crescents in bowman space (of glomeruli)
the crescents seen in RPGN are composed of _____ and _______
fibrin and macrophages
IgA nephropathy displays what type of casts?
RBC
- young patient
- episodic gross or microscopic hematuria with RBC casts
- follows mucosal infection (eg gastroenteritis)
IgA nephropathy (berger disease)
alport syndrome is due to an inherited defect in type ____ collagen
type IV
what is the inheritance of alport syndrome?
X linked
- isolated hematuria
- sensory hearing loss
- ocular disturbances
- x linked
alport syndrome
