Thurs Wk 3 Infectious Disease 3 Flashcards
Pneumocystis is acquired via __ into alveolar space
pt w impaired __ immunity cannot clear pathogen
strains of Strep pneumo that do not express a capsule are non__
they can take up genetic material from environment to encode proteins via __
also seen in H, B, N
once introduced, foreign bodies are coated in proteins like F/F
binding site for S__
leads to production of extracellular __ matrix
interferes w opsons, PMN __ and T cell activation
can eventually __ and spread infections
inhalation
cell mediated
pathogenic
transformation
Haemophilus, bacillus, neisseria
fibronogen, fibronectin s epidermidis polysaccharide migration disseminate
L__ is gram positive rod that can multiply at refrigerated temps
important in __ illness w contaminated products
may present w __ in healthy pt
sepsi/meningoenceph in those w impaired __ immunity
can lead to __ labor in 3rd trimester w neonatal sepsis
S__ is old aminoglycoside used in Tularemia, Tb, and Plague
inhibits __ rRNA of 30s ribsomal subunit
can have resistance w modified __ binding site
B__ is gram neg anaerobic rod that can produce B lactam
tx w __/__
also can use M, C, C
F__ are not active against anaerobes
listeria
foodborne
cell mediated
premature
streptomycin
16s
ribosomal
bacteroides
BL/BLI
metro, clindamycin, carbapenem
fluoroquinolones
P auerigonosa produces antibiotic modifying enzymes acquired from P/T
acyclovir is eventually incorporated into viral __ to stop DNA synthesis
these are N__ analogs
F__ is used for ganciclovir resistant CMV
can chelate __ and promote Mg wasting
also dec release of __ contributing to hypocalcemia
electrolyte abnorms may lead to __
C__ is used for CMV retinits
assc w N__ as se
plasmids, transposons
DNA
nucleoside
foscarnet
Calcium
PTH
seizures
cidofivir
nephrotoxicity
Ether/organic solvents inactivate __ viruses
disruption of envelope leads to loss of __
\_\_ is unenveloped, ssRNA spread FO in developing countries dz is usually \_\_ limiting detect HEV RNA or \_\_ in stool inc LFT and IgM \_\_ rise w illness concern is fulminant hep in \_\_
pseudomembrane in Diptheria is composed of bacteria, __ and leuks
binds to mucosa and will __ if removed
diptheria toxoid vaccina produces neutralizing antibodies against __ subunit of diptheria exotoxin
prevents attaching to host cell membrane __
enveloped
infectivity
HepE self HEV ag anti-HVE pregnant woman
fibrin
bleed
B
receptors
multiple painful, ragged ulcer w grey exudate is __
curved, gram neg rod in __ pattern
Lymphoma granuloma venereum caused by C__
small, shallow __
large, painful inguinal LN aka __
intracytoplasmic chlamydial inclusion bodies in __ cells and leuks
Granuloma inguinale by K_
extensive, progressive ulcers w/out __
base may have G_ tissue
look for intracytoplasmic __
H ducreyi
clumped
chlamydia
ulcers
buboes
epithelial
klebsiella granulomatis
LAN
granulation
cysts
Adenovirus is __ limited acquired via direct contact, FO, or resp
usually outbreaks in __
sx can include __ fever w fever, cough, pharyngitis, congestion, conjunctivitis
may progress to __
ds__
coxsakievirus can lead to __ dz w vesicles
or H__ w fever and posterior pharyngeal vesicles w/out rash
pt w slow growing facial mass w draining yellow pus has __
abscess has cutaneous __ track
tx w prolonged P__
tx anthracis w F__
self crowds Pharyngoonjunctival PNA DNA
HFM
herpangia
actinomycosis
sinus
penicillin
fluoroquinolones
Hib requires media w factor X __ and factor V ___
can be cultured w __ which produces NAD+ and releases hematin via RBC lysis
called the __ phenomena
Bronchiolitis is LRI caused by __
starts w __ and congestion, w low fever
progresses to hypoxemia and retractions w __ and crackles
seen in pts < __ yo
virion w phospholipid containing particle surface is an __ virus
usually acquired through budding into __ of cell, as in __ virus
CMV buds through host cell __ membrane
hematin, NAD+
Staph aureus
satellite
RSV
rhinorrhea
wheezing
2
enveloped
plasma membrane, mumps
nuclear
viral tropism depends on viral __ proteins for host cell receptors
must have high binding __ for glycoprotein receptor
mutation thus dramatically __ tropism
influenza has __ that can cleave viral RNA primers called cap snatching
Amphotercin and N__ are related in mechanism
amphotercin is __ while Nystatin is topical for Candida
Influenza viruses are O__
contain HA/NA on separate RNA __ allowing for genetic reassortment
Phenotypic mixing is not able to produce __ transmission
surface
affinity
canges
endonuclease
nystatin
systemic
orthomyoxyviruses
segments
sustained
Foscarnet does not require __
pyrophosphate analog that inhibits DNA polymerase in __ virus and RT in __
can also be useful in pt w _ infections
Gangiclovir must be __ by viral kinase and then cellular kinases
NRTI must be __ to active form
Ethambutol optic neuropathy is dec __ and central scotoma or RG __
PNA causes lung __ infection
usually __ infection
look for __ and fever
Pneumonitis causes parenchymal __
aspirated __
occurs __ after event
may have RDS
activation
herpes, HIV
herpes
activated
phosphorylated
acuity, color blindness
parenchymal
anaerobic
sputum
inflammation
Gastric Acid
hours
pt w febrile illness and intraerythrocytic organisms from NE US likely has __
skin and soft tissue infection w/in 24hrs of dog bite is likely __
gram neg coccobacillus w __ like odor
dogs can also transmit S, S
tx w A/C
Bartonella henslae is assc w __ and produces LAN
C trachomantis is obligate __ bacteria
serotypes A-C cause __ infection in kids
serotypes D-K cause __ infection
L1-L3 cause L__
if untx, can lead to fibrosis, obs, and F__
see mixed granulomatous/PMN infiltration w intracytoplasmic __ bodies
babesiosis
Pasturella
mousy
staph, strep
amoxicillin/clavulonate
cat scratch
intracellular ocular urogenital lymphogranuloma venereum fistula inclusion
pt w high grade fever, HA, retroorbital pain, bleeding, macular rash, muscle/joint pain likely has __ hemorrhagic fever
Leuk/platelets are __ w inc liver enzymes
primary infection is __ and individuals develop immunity
secondary infection w other __ leads to severe presentaton
due to inc capillary __ w marked thrombocytopenia, resp/circ failure and shock
__ test is positive, where pt has petechiae w torniquet applied
Anti-HBeAg in chronic infection indicates _ infectivity
V__ can tx diptheria
dengue low asx serotypes permeability Tourniquet
low
vancomycin
primary HSV1 presents w G__
systemic sx w painful __ on lips, gingiva, palate, tongue, pharynx
pain results in __
Reactivation of HSV is limited to the __
called herpes __
abortive infection enters cell but does not produce new __
thus, it does not cause __
use A__ for disseminated fungal infections
Significant SE is N__
hypokalemia can lead to weakness and __
ECG shows Twave __ w ST __, prominent Uwaves and PVC/PAC
this is due to inc distal __ membrane permeability
gingivostomatitis
vesicles
dehydration
lips
labialis
virus
disease
amphotercin nephrotoxicity arrhythmias flattening, depression tubule
antiHBs is a __ antibody that prevents viral entry
__ is a virus w 6+ genotypes
due to RNA dep RNA poly not have __ activity, thus resulting in mutations
as virus replicates, variant strains differ at __ genomic regions
thus, novel envelope glycoproteins prevent mounting of __
ETEC colonizes SI via __ and produces heat LT/ST
heat LT is like __ upregulting cAMP
heat ST inc __ in cell
both dec reabsorption and inc secretion resulting in __ diarrhea
EHEC does not __ mucosa
neutralizing
HCV
proofreading
hypervariable
immune response
pili
cholera
cGMP
watery
invade
pt w central venous catheter and parenteral nutrtion has high likelihood of C__
lipid emulsion aids in __
morphology shows budding __ w blastoconidia
E__ are found on outer membrane of gram neg
released w destrxn of __
has O antigen, core PS and lipid __, which is responsible for toxic properties of shock
E coli neonatal meningitis is caused by __ capsular antigens
candidemia
growth
pseudohyphae
endotoxins
cell wall
A
K1
HIV pt w fever, wl, and diarrhea indicate __
also see marked anemia, HSM and inc __/__ due to involvement of RES
resistant to most __ drugs
tx disseminated infection w C/A w Rifabutin/ethambutol
prophylaxis is w __
P jirovecii needs prophylaxis w __ at CD<200
w oropharyngeal __
T gondii needs TMP-SMX prophylaxis at CD< __
also w positive toxo __ antibody
MAC is acquired w CD4
MAC ALP, LDH Tb clarithro/azithromycin azithromycin
TMP-SMX
candida
100
IgG
50
Itraconazole
150
