Monday Wk 2 Pulm 3.5 Flashcards
Legionella has unique ___ on outer membrane which inhibits gram staining
test for legionella antigen in __
tx w resp __ or new M__
PPSV23 vaccine contains capsular material for __ serotypes
produces __ B cell response, thus it is less effective
PCV13 consists of __ serotypes
conjugated to the __ toxin, resulting in an improved immune response
lipopolysaccharide chain
urine
Fluoroquinolone, macrolide
23
T cell independent
13
diptheria
T__ is adenosine receptor antag and PDE inhib used as alternate therapy for asthma/COPD
causes bronchodilation by in __ conc
metabolized by __ system in liver
thus, interactions can cause toxicity due to narrow __
sx include __ stim w tremor, seizure, GI distubs, CV abnorms (hypoTN, cardiac ___)
Theophylline cAMP cyp450 therapetuic window CNS, arrhythmias
possible tx for OSA is to stimulate the __ nerve
causes tongue to move forward, thus inc AP __ of airway
Skin lesions, bilateral hilar adenopathy, resp sx and lofgren syndrome in AA pt should suggest __ as dx
high levels of serum __/__ due to granuloma prodxn
differentiate from other ILD via CD4/CD8 ratio, which should have __ CD4 count
__ predominates in hypersenitivity pneumonitis
hypoglossal
diameter
sarcoid
ACE/Calcium
high
CD8
__ is neutral protease produced by macro lysosomes and azurophilic granules of PMN
PMN elastase inhib by serum ___
macrophage elastase inhib by ____
elastase
A1AT
TIMPs
helper t cells that have not yet contacted antigen are __ T cells
have both CD__/__ and TCR
if antigen is presented by macro, __ will be released to form TH1
__ released by DC promote __ subset
pt w IL12 def cannot form __ cells
thus, cannot kill __ bacteria and viruses
naive
CD3/4
IL12
IL4, TH2
Th1
intracellular
__ is characterized by SOB, nodular densities, calcified hilar LN and birefringent particles
__ calcification is common
__ presents w SOB, ill defined nodular opacities
biopsy shows noncaseating granulomas w out ___
___ presents sob/nodular interstitial opacities
biopsy shows accumulation of __ laded macros (coal macules)
inhalation of __ leads to HP
biopsy shows __ granulomas
silicosis
eggshell
berrylosis
particles
CWP
carbon
organic dust
noncaseatng
bicarb less than __ indicates acute respiratory acidos
bicarb greater than __ indicate acute resp alkalosis
30
18
Fetal circ
oxygenated blood from placenta to the fetus via __
remnant in adult is L__
blood from umbilical vein goes to liver, bypassing circulation via D___ into IVC
blood is then delivered to __ circ or to LH via FO
blood then pumped down __ into tissues
deox blood then taken to mother via ___
umbilical veins
ligamentum teres hepatis
DV
pulm
descending aorta
umbilical arteries
__ is transmitted via thorn pick
pustules, ulcers, subQ nodules along lymphatics
in culture, forms branching __
on biopsy, shows round/__ shaped budding yeast
Paracoccidioides brasilensis
found in __/__ america
chronic __/__ ulcers progressing to LN/lungs
culture shows multiple __
biopsy shows cells covered w __
Sporothrix
hyphae
cigar
C/S
mucocutaneous/cutaneous
blastoconidiai
blastoconidia
capsule in Hib composed of PRP ___
binds factor __ to prevent C3B complement deposition on host cells
Trehalose dimycolate is cell wall compoent/virulence factor for __
prevents __ by macros and stimulates __ formation
polyribositol phosphate
H
Tb
killing, granulom
in pt w out CF, CFTR facilitates production of __ sweat
supplement __ in pt w CF
hypotonic
salt
__ impairs macrophage effectors of cell mediated immunity
phagosome is disrupted via __ particles, leading to release of particles and __ into periphery
eventually, this leads to macrophage __
thus, IS is not able to __ the infection
release of __ enzymes thought to cause ILD in silicosis
SIlicosis
intracellular, mycobacteria
apoptosis
control
lysosomal
SCLC can secrete \_\_ resulting in SIADH tumor stains for \_\_ markers such as NCAM aka \_\_ neuron specific E/C/S may express N\_\_ identify \_\_ granules in cytoplasm of tumor cells
mucin and EGRF seen in __
sarcomas express V__
vasopressin neuroendocrine CD56, enolase, chromogranin, synaptophysin neurofilaments neuroscretory
NSCLC
vimentin
pulm vasc bed is unique in that hypoxia results in __
directs blood from __ region to better ventilated areas
in systemic circ, hypoxia results in __
coronary vasc subendocardial blood flow is dteremnined by A/N
VC
under ventilated
vasodilation
adenosine, NO
Avitaminosis A can be seen in __
presents w __ meatplazia to __ epithelia
VA maintains differentiation of specialized epithelia like mucus secreting __ epithelia of ocular conjunctiva, R/U tract, and P ducts
__ def can lead to infertility and dec serum phospholipids
CF
squamous, keratinizing
columnar, resp, urinary, panc
VE
