Friday Heme 4.5 Flashcards
pt w aplastic anemia has low numbers of __
__ is inc by kdney
iron/haptoglobin should be __
white cells in aspirate should appear morphologically __
__ anemia presents w short stature and absent thumbs
inc risk of __ malig
Parvo infection only produces aplastic crisis in pt w preexisting __ dz
all cell lines
EPO
normal
normal
hematologic
cells undergoing DNA synthesis must be in the __ phase of cell cycle
normally inhibited by __ in hypophosphorylated form
if cell is stimulated by GF, activation of cyclin / and CDK4/6 phosphroylates Rb
releases __ to allow cell prog
if Rb is hypophos, it is bound to __ acting as break
p27 is cell cycle inhibitor
inhibits __ at high levels
S
Rb
D, E
E2F
E2f
CDK kinases
in bruise, Hb containing E__ escape to tissue
gives bruse the __ color
destruction releases heme, and is degraded by HO into biliverdin
this produces the __ color
biliverdin eductae then degrades it to __ which is transported to the liver
may see __ color
enterocytes blue heme oxygenase green bilirbin yellow
ALAS is inhibited by G/H
PBG Deaminase pt are asx until induction of __
__ carcinomas arise from transitional epithelium of bladder
presents w painless __
usually resemble normal __, called urotheial ca
SCC/adeno are __
can grow as papillary or __ mass
__ indicates confined to epithelium
further penetration has __ prognosis
glucose/hemin
ALAS
bladder
hematuria
epithelium
rare
sessile
CIS
poor
pt w eczema, recurrent infections and thrombocytopenia has __ dx
inheritance is __
combined _/__ cell disorder
at risk for __ org infections
T cell defect leads to susceptibility for P/H infections
pt is symptomatic after losing __/__ from mother at 6m
tx w HLA matched ___
C__ syndrome presents w oculocutaneous albinism, peripheral Neuro, and immunodef of phagosome/lysosome fusion
Wiscott Aldrich X linked B cell, T cell encapsulated pneumocystis, herpes IgG, IgA bone marrow transplant
chediak higashi
tx of HER2 neu occurs w monoclonal ab __
tx ER pos BC w estrogen Receptor modulator T (premen)
or aromatase inhibs A/L (post men)
use RANKL antibody D to inhibit OC
vWF deficiency has __ pattern of inheritance
trastuzumab
tamoxifen
anastrozole, letrozole
denosumab
AD
pt w sx of anemia, but normal WBC/platelets and marrow precursors has __ aplasia
caused by severe hypoplasia of __ elements w normal granulo/thrombopoeisis
IgG/CD8 T cells inhibits __ precursors
assc w T/L
w thymoma, removal can __
can also be due to __ infection, as it attacks p__
look for infection w presence of anti-B19 __ in serum
pure red cell aplasia
marrow
RBC
thymoma, lymphocytic leukemia
cure
parvo
promyeloblasts
IgM
VEGF and __ can stimulate angiogenesis
VEGF inc endothelial cell __ and prolifration
FGF is important in endothelial __ and Migration and differentiation
may stimulate __
important in H__ and wound repair
IL1 and INFG can stimulate macrophages, which can release __
Laminin in basement membrane can __ sprouting blood vessels
FGF
motility
proliferation
angioblasts
hematopoeisis
VEGF
inhibit
HbA1c is elevated w high __ or long __ of red cells to glucose
HbA2 is upregulated in __ to compensate for dec beta chains
this can falsely dec __ in pt
HUS causes thrombocytopenia by damaging __, resulting in platelet adherence
microthrombi then __ platelets
damage to glomerular __ cells results in AKI
platelet count is __
all other clotting studies are __
gucose, exposure
B thalassemia
HbA1c
endothelium
shear
endothelial cells
low
normal
osteomyelitis in Sickle cell pt is S, then S and E
vinca alkaloids disrupt __ mcrotubules responsible for transporting organelles/cell products bw neuron cell body and axon terminal
phase G2 of cell cycle, DNA is checked for __
if cannot be corrected, apoptosis will result unless __ mutation occurs
drugs like B/D act here
__ is cell cycle nonspecific
salmonella, staph, e coli
neuronal
mutations
loss of fxn
bleomycin, doxorubicin
cyclophosphamide
AI hemolytic anemia is not __
coombs test is ___
have propensity for __ AI cx
pt w excessive __ can have excessive bleeding
labs wil be __ except for inc __
tx w __
inherited
positive
other
uremia
normal, bleeding time
dialysis
