Monday Wk 4 Derm 2 Flashcards
Sporothrix is a d__ fungus
commonly found in bark, shrubs, plants and enters via __ in skin
biopsy shows G__ w histiocytes, giant cells, PMN and plasma cells
dx w c__ of affected area
tx w I__
BP is AA against __ of dermal-epidermal jxn
causes __ w subepidermal, non acantholytic blisters
IF shows IgG, C3 in __ pattern
acute allergic contact dermatitis shows localized redness, vesicles, edema and severe P__
biopsy shows S__ w abnormal accumulation of edema in intracellular spaces and lymphocytic infiltrates
dimorphic breaks granlomas culture itraconazole
hemidesmosomes
separation
linear
pruritis
spongiosis
LP has __ infiltrate at D/E jxn w destxn of basal epidermal cells
DH has basal cells w _ at tips of involved papillae
UVB concentrates in D__
UVA goes deeper and causes photoA__
releases __ to activate multiple cell surface receptors and nuclear TF
this dec collagen __ prodxn w upregulated MMP
loss of type __/__ collagen and elastin
leads to graual thinning of _
dermal atrophy w inc __ of collagen and dessication of SC leads to wrinkling
also see flattening of __ ridges
lymphocytic
scar
dermis aging ROS fibril 1, 3 epidermis crosslinking rete
may see achondrocons in areas of A__
Malignant AN is assc w __/__ tract neoplasm
esp __ adenocarcinoma
hemangiomas have small areas of capillaries surrounded by thin __ w CT
spliceosomes remove introns w __ at 5’ site and __ at 3’ splice site
__ is transmitted via respiratory droplets and manifests as chicken pox in kids
travels via sensory fibers to dorsal root ganglion until reactivated to S__
LM shows intranuclear __ w multinucleated giant cells
skin biopsy shows A__
LM of PV shows IgG in __ pattern
Eosinophilic cytoplasmic inclusions indicates __
AN
GI/GU
gastric
endothelium
GU, AG
VZV
shingles
inclusions
acantholysis
reticular
molluscum contagiosum
Atopic eczematous dermatitis shows intradermal V__ and superficial epidermal hyper__ w scales, epidermal hyperplasia and chronc inflam infiltrate
along w chronic CS use, leads to dermal __
dec prodxn of ECM C and G leads to drying, cracking, tightening of skin
Telangectasias and E__ may develop
LLM of xanthomas enclosed by inflam __ and fibrotic stroma
NAD is necessary for CAC enzymes like isocitrate/a ketoglutarate, malate __
Succinate dehydrogenase requires __ as cofactor
vesicles, plasia
atrophy
collagen, GAG
ecchymoses
cells
dehydrogenase
FAD
GVHD can occur in __ transplants
or in organs rich in lymphs like __
immunocompetent Donor T cells from graft migrate to hist tissues and recognize host __ as foregin
this activates __/__ t cells for host cell destruction
leads to diffuse rash of __/__ that may desquamate
also leads to D_ and intestinal bleeding/ab pain
liver damage leads to abnormal __
Acute/chronic rejection affects the transplanted __ w out affecting other organs
BM liver MHC CD4/CD8 palms, soles diarrhea LFTs
organ
rubella rash does not __ and spreads faster than measles
Coltivirus is part of R__
causes Coloradeo __ fever w f, vomiting, myalgia, weakness
melanoytic __are benign neoplasms of uniform melanocytes
less than __ mm and have regular, sharp border
start as __ nevi w aggregates of nevus cells limited to DE jxn
appear flat and darker at __ than periphery
C__ nevi form as extension to dermis
become __ w uniform color as it involves D and E
I__ nevi are older and epidermal cells lost
lose __ activity and no pigment is found, may be pedunculated
darken
Reoviridae
tick
nevus 6 jxnal center compound raised intradermal tyrosinase
melanoma cells are __ and have larger, more mitotically active cells
Pigmented BC has rolled border that extends into D__ w palisading arrangement
pt w tuberculoid leprosy will have indurated __ in lepromin skin test
will be nonreactive in __ leprosy due to weak TH1 activity
major RF for melanoma is __ radiation
also can have mutation in __ a protein kinase in signaling pathway
V600E which is valine to _ inc activation
tx w V__ an anti-BRAF drug
larger
dermis
nodule
lepromatous
UV
BRAF
glutamic acid
vemurafenib
Erythema __ is inflam disorder of skin and oral mucosa/tongue if severe
erythematous, round, __ lesions w dusky center and dark red inflam zone and halo in periphery
represents a __ mediated process, w inflam infiltrate of CD8 t cells
usually assc w H/M infection due to immune response to antigens in skin
also seen w S, M, C__ vasc dz
SJS has rapid onset erythematous macules w necrosis and skin S__
multiforme
target
cell
herpes, mycoplasma
sulfonamides, malignany, collagen
sloughing
Atopic dermatitis is assc w environmental __
red, __ lesions of face, flexural areas
may have L_ in older kids
look for intense __ as hallmark
due to impaired barrier function of __ like filagrin
high serum __ and peripheral __ w inc cAMP
look for FH of __ disorders and allergic rhinitis/asthma
chronic lymphedema is RF for cutaneous A_ aka Stewart Treves Syndrome
such as radical mastectomy w axillary LN D__
histo shows infiltration of D_ w slit like abnormal vasc spaces
irritation weeping lichenification pruritis skin IgE, eosinophilia allergic
angiosarcoma
dissection
dermis
Febrile neutropenia is ANC less than __
inc susceptibility to gram neg like __
Ecthema __ is perivasc bacterial invasion of arteries/veins in dermis/subq
release of E__ leads to skin patches w necrosis and ulceration
typically due to P__
small bright red papular lesion is __ hemangioma in older person
bening v__ tumor that is only in superficical skin
sharp areas of congested __ and post cap venules
C__ hemangioma is blue and compressable
usually found in __ if in skin
500 Pseudo gangrenosum exotoxins Pseudo
cherry
vascular
capillaries
cavernous
dermis
___ stem of tRNA creates base pair of 5’ terminal nucleotides w 3’ terminal nucleotides
__ loop has dihydrouridine residues w modified bases to facilitate tRNA- amino acyl tRNA synthetase interaction
__ loop has ribothymidine, pseudouridine, and cytidine residues for binding to ribosome
A_ is ertyhematous papules w whitish scale that has sandpaper feel
hyperkeratosis may lead to cutaneous __
Pitryiasis R__ begins as solitary pink/brown plaque w clearing
followed by formation of ovoid rash w lesions in __ direction along skin lines
known as __ pattern
acceptor
D
T
actinic keratosis
horn
rosea
oblique
Christmas tree
xeroderma pigmentosum presents in 1st year w severe sun __
telangectasia and mixed hypo/hyper__ develops w chronic damge
mutation in genes responsible for repair of interstrand DNA crosslinks is _ anemia
M__ cells form nests w large irregular nuclei, clumped chromatin and prominent nucleoli
initial growth is R__ and horizontal/superficial
V__ growth occurs into dermis, w inc risk for metastasis
most important prognostic factor is __ depth- distance from __ granular cell layer to deepest visible melanoma cell
sensitivity
pigmentation
Fanconi
melanoma radial vertical Breslow epidermal
Multinucleated giant cells are found in L__ maligna melanoma
pigmented lesion of __ as precursor to melanoma
U__ is intensely pruritic, raised erythematous plaques called wheals arising over hrs
can be IgE _/__ or mast cell independent
due to inc permeability of microvasculature w __ of superficial dermis
deeper involvement is A__
biopsy shows mixed __ infiltrate around dermal venules
lymphatic venules are engorged w T__ fluid
lentigo
skin
urticaria dependent/independent edema angioedema inflammatory transudative
acute eczematous dermaitis characterized by S__ w edema in epidermis
intracellular bridges and v__ form
perivascular infiltrate of L/E
becomes less weepy/edematous w subsequent __
leads to thickening of SS (acanthosis) and SC (hyperkeratosis) produces a P__
D__ is abnormal, premature keratinization of individual keratinocytes
may be seen in S__
hypergranulosis is inc thickness of __ seen in LP
spongiosis
vesicles
lymphs, eosinophils
exposure
plaque
Dyskeratosis
SCC
SG
